5crh

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m (Protected "5crh" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Human skeletal calsequestrin, M53T mutant high-calcium complex==
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<StructureSection load='5crh' size='340' side='right' caption='[[5crh]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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The entry 5crh is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5crh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CRH FirstGlance]. <br>
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Authors: Lewis, K.M., Ronish, L.A., Kang, C.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5crd|5crd]], [[5cre|5cre]], [[5crg|5crg]]</td></tr>
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Description: Human skeletal calsequestrin, M53T mutant high-calcium complex
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5crh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5crh OCA], [http://pdbe.org/5crh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5crh RCSB], [http://www.ebi.ac.uk/pdbsum/5crh PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Ronish, L.A]]
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== Function ==
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[[Category: Lewis, K.M]]
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[[http://www.uniprot.org/uniprot/CASQ1_HUMAN CASQ1_HUMAN]] Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction.<ref>PMID:22337878</ref> <ref>PMID:22337878</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Kang, C]]
[[Category: Kang, C]]
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[[Category: Lewis, K M]]
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[[Category: Ronish, L A]]
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[[Category: Calcium binding protein]]

Revision as of 13:52, 7 October 2015

Human skeletal calsequestrin, M53T mutant high-calcium complex

5crh, resolution 2.03Å

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