Cyclin-dependent kinase
From Proteopedia
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{{STRUCTURE_3rgf| PDB=3rgf | SIZE=400| SCENE= |right|CAPTION=CDK8 (grey) complex with cyclin C (green), sorafenib drug and glycerol (PDB code [[3rgf]]) }} | {{STRUCTURE_3rgf| PDB=3rgf | SIZE=400| SCENE= |right|CAPTION=CDK8 (grey) complex with cyclin C (green), sorafenib drug and glycerol (PDB code [[3rgf]]) }} | ||
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| - | '''Cyclin-dependent kinase''' (CDK) are serine/threonine kinases which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein cyclin. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human.<br /> | + | '''Cyclin-dependent kinase''' (CDK) or '''Cell division protein kinase''' are serine/threonine kinases which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein cyclin. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human.<br /> |
| - | • | + | • '''CDK2''' is involved in the control of the cell cycle. It interacts with the regulatory protein cyclin A2. Phosphorylation at Thr14 or Tyr15 inactivates it; phosphorylation at Thr160 (T160P) – activates it. See also [[Intrinsically Disordered Protein]].<br />see [[Cell Division Protein Kinase 2]]. <br /> |
• '''CDK3''' binds cyclin C and functions during the G1 phase. <br /> | • '''CDK3''' binds cyclin C and functions during the G1 phase. <br /> | ||
• For details on '''CDK4''' see [[Cyclin Dependent Kinase-4]]. <br /> | • For details on '''CDK4''' see [[Cyclin Dependent Kinase-4]]. <br /> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| + | *CDK1 | ||
| + | |||
| + | **[[1dks]] – hCDK1 + phosphate - human<br /> | ||
| + | **[[1dkt]] – hCDK1 + vanadate <br /> | ||
| + | **[[4yc6]] – hCDK1 + cyclin-dependent kinase regulatory subunit 1<br /> | ||
| + | **[[4y72]] – hCDK1 + cyclin-dependent kinase regulatory subunit 2 + cyclin B1<br /> | ||
*CDK2 | *CDK2 | ||
| - | + | **[[1pw2]], [[1hck]], [[1hcl]], [[1b38]], [[4ek3]] – hCDK2 – human<br /> | |
| + | **[[1b39]] - hCDK2 T160P<br /> | ||
| + | **[[3ns9]], [[3le6]], [[2xmy]], [[2xnb]], [[3lfn]], [[3lfq]], [[3lfs]], [[3ig7]], [[3igg]], [[3fz1]], [[3ezr]], [[3ezv]], [[2w1h]], [[2w17]], [[2w05]], [[2w06]], [[2r64]], [[2vta]], [[2vth]], [[2vti]], [[2vtj]], [[2vtl]], [[2vtm]], [[2vtn]], [[2vto]], [[2vtp]], [[2vtq]], [[2vtr]], [[2vts]], [[2vtt]], [[2vu3]], [[2vv9]], [[2r3f]], [[2r3g]], [[2r3h]], [[2r3i]], [[2r3j]], [[2r3k]], [[2r3l]], [[2r3m]], [[2r3n]], [[2r3o]], [[2r3p]], [[2r3q]], [[2r3r]], [[2j9m]], [[2v0d]], [[2duv]], [[2clx]], [[2fvd]], [[2a4l]], [[1w8c]], [[2a0c]], [[2exm]], [[2bpm]], [[2c68]], [[2c69]], [[2c6i]], [[2c6k]], [[2c6l]], [[2c6m]], [[2c6o]], [[2c6t]], [[2btr]], [[2bts]], [[2b52]], [[2b53]], [[2b54]], [[2b55]], [[2bhe]], [[2bhh]], [[1y8y]], [[1y91]], [[1wcc]], [[1w0x]], [[1pye]], [[1vyz]], [[1vyw]], [[1v1k]], [[1urw]], [[1pxm]], [[1pxn]], [[1pxo]], [[1pxp]], [[1r78]], [[1pf8]], [[1pxi]], [[1pxj]], [[1pxk]], [[1pxl]], [[1oiq]], [[1oir]], [[1oit]], [[1p2a]], [[1h00]], [[1h01]], [[1h07]], [[1h08]], [[1h0v]], [[1h0w]], [[1gz8]], [[1ke5]], [[1ke6]], [[1ke7]], [[1ke8]], [[1ke9]], [[1gih]], [[1gii]], [[1gij]], [[1jvp]], [[1g5s]], [[1jsv]], [[1e1v]], [[1e1x]], [[1fvt]], [[1fvv]], [[1di8]], [[1dm2]], [[1ckp]], [[1aq1]], [[3pxf]], [[3pxq]], [[3pxr]], [[3pxy]], [[3pxz]], [[3py0]], [[3py1]], [[3pj8]], [[3s2p]],[[3ql8]], [[3qqf]], [[3qqg]], [[3qqh]], [[3qqj]], [[3qqk]], [[3qrt]], [[3qru]], [[3qtq]], [[3qtr]], [[3qts]], [[3qtu]], [[3qtw]], [[3qtx]], [[3qtz]], [[3qu0]], [[3qwj]], [[3qwk]], [[3qx2]], [[3qx4]], [[3qxo]], [[3qxp]], [[3qzf]], [[3qzg]], [[3qzh]], [[3qzi]], [[3r1q]], [[3r1s]], [[3r1y]], [[3r28]], [[3r6x]], [[3r71]], [[3r73]], [[3r7e]], [[3r7i]], [[3r7u]], [[3r7v]], [[3r7y]], [[3r83]], [[3r8l]], [[3r8m]], [[3r8p]], [[3r8u]], [[3r8v]], [[3r8z]], [[3r9d]], [[3r9h]], [[3r9n]], [[3r9o]], [[3rah]], [[3rai]], [[3rak]], [[3ral]], [[3rjc]], [[3rk5]], [[3rk7]], [[3rk9]], [[3rkb]], [[3rm6]], [[3rm7]], [[3rmf]], [[3rni]], [[3roy]], [[3rpo]], [[3rpr]], [[3rpv]], [[3rpy]], [[3rzb]], [[3s00]], [[3s0o]], [[3s1h]], [[3sqq]], [[3sw4]], [[3sw7]], [[3ti1]], [[3tiy]], [[3tiz]], [[3uli]], [[3unj]], [[3unk]], [[3wbl]], [[4acm]], [[4bgh]], [[4ek4]], [[4ek5]], [[4ek6]], [[4ek8]], [[4ez3]], [[4ez7]], [[4fkg]], [[4fki]], [[4fkj]], [[4fkl]], [[4fko]], [[4fkp]], [[4fkq]], [[4fkr]], [[4fks]], [[4fkt]], [[4fku]], [[4fkv]], [[4fkw]], [[4gcj]], [[4kd1]], [[4lyn]], [[4nj3]], [[4bzd]], [[4rj3]] – hCDK2 + inhibitor<br /> | ||
| + | **[[2ds1]] – hCDK2 (mutant) + inhibitor<br /> | ||
| + | **[[1fq1]] - hCDK2 +cyclin-dependent kinase inhibitor 3<br /> | ||
| + | **[[1buh]] – hCDK2+ protein CKSHS1<br /> | ||
| + | **[[4erw]] – hCDK2 + staurosporine<br /> | ||
| + | |||
| + | *CDK2+cyclin | ||
| + | |||
| + | **[[2jgz]] - hCDK2 T160P + cyclin B1<br /> | ||
| + | **[[1w98]] - hCDK2 + cyclin E1<br /> | ||
| + | **[[2wma]], [[2wmb]], [[2x1n]], [[2wev]], [[2wfy]], [[2whb]], [[2v22]], [[2cch]], [[1okv]], [[1okw]], [[1ol1]], [[1ol2]], [[1urc]], [[1h24]], [[1h25]], [[1h26]], [[1h27]], [[1h28]], [[1gy3]], [[3qhr]], [[3qhw]] - hCDK2 + cyclin A2+peptide ligand<br /> | ||
| + | **[[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[2uzb]], [[2uzd]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[1ykr]], [[2c4g]], [[1p5e]], [[1pkd]], [[1fin]], [[4bcm]], [[4bcn]], [[4bco]], [[4bcp]], [[4bcq]], [[4cfm]], [[4cfn]], [[4cfu]], [[4cfv]], [[4cfw]], [[4cfx]], [[4fx3]] – hCDK2 + cyclin A2 + inhibitor<br /> | ||
| + | **[[3ddp]], [[3dog]], [[3ddq]], [[3bht]], [[3bhu]], [[3bhv]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[2cjm]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[1jst]], [[3tnw]], [[4bck]], [[4eoi]], [[4eoj]], [[4eok]], [[4eol]], [[4eom]], [[4eon]], [[4eoo]], [[4eop]], [[4eoq]], [[4eor]], [[4eos]] - hCDK2 T160P+ cyclin A2 + inhibitor<br /> | ||
| + | **[[2cci]], [[1qmz]] - hCDK2 T160P + cyclin A2+peptide ligand<br /> | ||
| + | **[[1e9h]] - hCDK2 T160P + cyclin A3 + inhibitor<br /> | ||
| + | **[[1jsu]] - hCDK2 T160P + cyclin A2+ protein P27<br /> | ||
| + | **[[4i3z]], [[4ii5]] - hCDK2 T160P + cyclin A2+ ADP<br /> | ||
*CDK3 | *CDK3 | ||
Revision as of 07:45, 11 October 2015
Template:STRUCTURE 3rgf
Cyclin-dependent kinase (CDK) or Cell division protein kinase are serine/threonine kinases which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein cyclin. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human.
• CDK2 is involved in the control of the cell cycle. It interacts with the regulatory protein cyclin A2. Phosphorylation at Thr14 or Tyr15 inactivates it; phosphorylation at Thr160 (T160P) – activates it. See also Intrinsically Disordered Protein.
see Cell Division Protein Kinase 2.
• CDK3 binds cyclin C and functions during the G1 phase.
• For details on CDK4 see Cyclin Dependent Kinase-4.
- CDK5 binds p53 and functions during transcription.
• CDK6 binds cyclin D and functions during the G1 phase.
• CDK7 may serve as a direct link between transcription regulation and the cell cycle.
• CDK8 binds cyclin C and functions during transcription.
• CDK12 phosphorylates the C-terminal domain of the large subunit of RNA polymerase II. Acts as a regulator of transcription elongation.
• CDK16 plays a role in vescicle-mdiated transport processes and exocytosis.
3D structures of cyclin-dependent kinase
Updated on 11-October-2015
