Cyclin-dependent kinase
From Proteopedia
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'''Cyclin-dependent kinase''' (CDK) or '''Cell division protein kinase''' are serine/threonine kinases which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein cyclin. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human.<br /> | '''Cyclin-dependent kinase''' (CDK) or '''Cell division protein kinase''' are serine/threonine kinases which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein cyclin. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human.<br /> | ||
| + | • '''CDK1''' binds cyclin and forms a complex which phosphorylates a variety of substrates which are involved in cell cycle progression. <br /> | ||
• '''CDK2''' is involved in the control of the cell cycle. It interacts with the regulatory protein cyclin A2. Phosphorylation at Thr14 or Tyr15 inactivates it; phosphorylation at Thr160 (T160P) – activates it. See also [[Intrinsically Disordered Protein]].<br /> | • '''CDK2''' is involved in the control of the cell cycle. It interacts with the regulatory protein cyclin A2. Phosphorylation at Thr14 or Tyr15 inactivates it; phosphorylation at Thr160 (T160P) – activates it. See also [[Intrinsically Disordered Protein]].<br /> | ||
• '''CDK3''' binds cyclin C and functions during the G1 phase. <br /> | • '''CDK3''' binds cyclin C and functions during the G1 phase. <br /> | ||
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**[[1dks]] – hCDK1 + phosphate - human<br /> | **[[1dks]] – hCDK1 + phosphate - human<br /> | ||
**[[1dkt]] – hCDK1 + vanadate <br /> | **[[1dkt]] – hCDK1 + vanadate <br /> | ||
| - | **[[4yc6]] – hCDK1 + | + | **[[4yc6]] – hCDK1 + CDK regulatory subunit 1<br /> |
| - | **[[4y72]] – hCDK1 + | + | **[[4y72]] – hCDK1 + CDK regulatory subunit 2 + cyclin B1<br /> |
*CDK2 | *CDK2 | ||
Revision as of 07:53, 11 October 2015
Template:STRUCTURE 3rgf
Cyclin-dependent kinase (CDK) or Cell division protein kinase are serine/threonine kinases which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein cyclin. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human.
• CDK1 binds cyclin and forms a complex which phosphorylates a variety of substrates which are involved in cell cycle progression.
• CDK2 is involved in the control of the cell cycle. It interacts with the regulatory protein cyclin A2. Phosphorylation at Thr14 or Tyr15 inactivates it; phosphorylation at Thr160 (T160P) – activates it. See also Intrinsically Disordered Protein.
• CDK3 binds cyclin C and functions during the G1 phase.
• For details on CDK4 see Cyclin Dependent Kinase-4.
- CDK5 binds p53 and functions during transcription.
• CDK6 binds cyclin D and functions during the G1 phase.
• CDK7 may serve as a direct link between transcription regulation and the cell cycle.
• CDK8 binds cyclin C and functions during transcription.
• CDK12 phosphorylates the C-terminal domain of the large subunit of RNA polymerase II. Acts as a regulator of transcription elongation.
• CDK16 plays a role in vescicle-mdiated transport processes and exocytosis.
3D structures of cyclin-dependent kinase
Updated on 11-October-2015
