Cyclin-dependent kinase regulatory subunit

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Revision as of 06:30, 12 October 2015

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spinqualitylabelsall models Human CKS 1 (PDB code 1dks) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image spinqualitylabelsall models Human CKS 1 complex with CDK1 (PDB code 4yc6) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Cyclin-dependent kinase regulatory subunit (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in the figure at top left. CKS1 is essential for CDK5 functioning in neuronal diferentiation. CKS exists as hexamer of homodimers and can bind six kinase molecules. Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Disease Relevance Structural highlights

3D Structures of cyclin-dependent kinase regulatory subunit

Updated on 12-October-2015 {{#tree:id=OrganizedByTopic|openlevels=0|

• CKS

• • 4lpa, 1qb3 – yCKS 1 - yeast
    
  • 3qy2 – yCKS 1 (mutant)
    
  • 1puc, 1sce – fyCKS 1 – fission yeast
    
  • 1dks, 1dkt – hCKS 1 - human
    
  • 1cks – hCKS 2
    

• CKS complexes

• • 4yc6 – hCKS 1 + CDK1
    
  • 1buh – hCKS 1 + CDK2
    
  • 1h4l, 1ung – hCKS 1 + CDK5
    
  • 1unh, 1unl – hCKS 1 + CDK5 + inhibitor
    
  • 3o0g – hCKS 1 + CDK5 + ATP analog
    
  • 2ass – hCKS 1 + Skp1 + Skp2
    
  • 2ast – hCKS 1 + Skp1 + Skp2 + CDK inhibitor peptide
    
  • 4y72 – hCKS 2 + cyclin B1 + CDK1
    

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References