RNA polymerase
From Proteopedia
(Difference between revisions)
| Line 22: | Line 22: | ||
* [[User:Michael Strong/H1N1/PA]]<br /> | * [[User:Michael Strong/H1N1/PA]]<br /> | ||
* [[User:Michael Strong/H1N1/PA/MSA]] | * [[User:Michael Strong/H1N1/PA/MSA]] | ||
| + | |||
| + | '''Poly(A) RNA polymerase''' catalyzes the addition of long poly(A) tails to mRNA. | ||
== 3D Structures of RNA polymerase == | == 3D Structures of RNA polymerase == | ||
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**[[3cqz]], [[1k83]] - yRNAP II + inhibitor<br /> | **[[3cqz]], [[1k83]] - yRNAP II + inhibitor<br /> | ||
**[[1twa]], [[1twc]], [[1twf]], [[1twg]], [[1twh]] - yRNAP II + nucleotide<br /> | **[[1twa]], [[1twc]], [[1twf]], [[1twg]], [[1twh]] - yRNAP II + nucleotide<br /> | ||
| + | |||
| + | *''DNA primase'' | ||
| + | |||
| + | **[[4lik]] - hDNAP small subunit<br /> | ||
| + | **[[4lil]] - hDNAP small subunit + UTP<br /> | ||
| + | **[[3q36]] – hDNAP large subunit<br /> | ||
| + | **[[4bpu]] - hDNAP small (mutant) + large subunit<br /> | ||
| + | **[[4bpw]] - hDNAP small (mutant) + large subunit + UTP<br /> | ||
| + | **[[4bpx]] - hDNAP small (mutant) + DNA polymerase α subunit<br /> | ||
| + | **[[4ehs]] – HpDNAP C terminal<br /> | ||
| + | **[[4lim]] - yDNAP small subunit<br /> | ||
| + | **[[3lgb]] - yDNAP large subunit<br /> | ||
| + | **[[3m1m]] – DNAP RNA polymerase domain – ''Sulfolobus islandicus''<br /> | ||
| + | **[[1zt2]], [[2pa8]], [[2pmz]], [[3hkz]] - DNAP small + large subunit – ''Sulfolobus solfataricus''<br /> | ||
| + | **[[2au3]] – DNAP zinc-binding and RNA polymerase domains – ''Aquifex aeolicus''<br /> | ||
| + | **[[1v33]] - PhDNAP small subunit – ''Pyrocuccus horikoshii''<br /> | ||
| + | **[[1v34]] - PhDNAP small subunit + nucleotide<br /> | ||
| + | **[[1g71]] - PfDNAP small subunit<br /> | ||
| + | **[[4e2k]] – SaDNAP – ''Staphylococcus aureus''<br /> | ||
| + | **[[2lzn]] – SaDNAP C terminal – NMR<br /> | ||
| + | **[[4edg]], [[4edk]], [[4edr]], [[4edt]], [[4edv]], [[4ee1]] – SaDNAP + nucleotide | ||
| + | |||
| + | *''Bacterial primase'' | ||
| + | |||
| + | **[[2r6a]], [[2r6c]] - GsdnaG helicase binding domain + helicase – ''Geobacillus stearothermophilus''<br /> | ||
| + | **[[4m4w]] - GsdnaG helicase binding domain + helicase + DnaI<br /> | ||
| + | **[[1d0q]] - GsDNAP zinc-binding domain<br /> | ||
| + | **[[1z8s]] - GsdnaG dnaB binding domain - NMR<br /> | ||
| + | **[[2haj]] - EcdnaG catalytic domain - NMR<br /> | ||
| + | **[[3b39]] – EcdnaG catalytic domain + DNA<br /> | ||
| + | **[[1t3w]] – EcdnaG C-terminal<br /> | ||
| + | **[[1eqn]], [[1dd9]], [[1dde]] – EcdnaG catalytic core<br /> | ||
| + | |||
| + | *''RNA polymerase from Bacteriophage T7'' | ||
| + | |||
| + | **[[1q57]] – T7DNAP/helicase (mutant) – Enterobacteria phage T7<br /> | ||
| + | **[[1nui]] – T7DNAP/helicase primase fragment (mutant)<br /> | ||
| + | **[[1cr0]] - T7DNAP/helicase helicase domain<br /> | ||
| + | **[[1cr1]], [[1cr2]], [[1cr4]] - T7DNAP/helicase helicase domain + nucleotide<br /> | ||
| + | **[[4rnp]] – T7RNAP<br /> | ||
| + | **[[1aro]] – T7RNAP + T7 lysozyme<br /> | ||
| + | **[[1cez]], [[1h38]], [[1qln]], [[2pi4]], [[2pi5]] - T7RNAP + DNA<br /> | ||
| + | **[[1msw]], [[1s0v]], [[1s76]], [[1s77]], [[3e2e]], [[3e3j]] - T7RNAP + DNA + RNA<br /> | ||
*RNA-dependent RNAP | *RNA-dependent RNAP | ||
| Line 307: | Line 352: | ||
**[[4wsb]] - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2 + RNA<br /> | **[[4wsb]] - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2 + RNA<br /> | ||
| - | |||
| - | *DNA primase | ||
| - | |||
| - | **[[4lik]] - hDNAP small subunit<br /> | ||
| - | **[[4lil]] - hDNAP small subunit + UTP<br /> | ||
| - | **[[3q36]] – hDNAP large subunit<br /> | ||
| - | **[[4bpu]] - hDNAP small (mutant) + large subunit<br /> | ||
| - | **[[4bpw]] - hDNAP small (mutant) + large subunit + UTP<br /> | ||
| - | **[[4bpx]] - hDNAP small (mutant) + DNA polymerase α subunit<br /> | ||
| - | **[[4ehs]] – HpDNAP C terminal<br /> | ||
| - | **[[4lim]] - yDNAP small subunit<br /> | ||
| - | **[[3lgb]] - yDNAP large subunit<br /> | ||
| - | **[[3m1m]] – DNAP RNA polymerase domain – ''Sulfolobus islandicus''<br /> | ||
| - | **[[1zt2]], [[2pa8]], [[2pmz]], [[3hkz]] - DNAP small + large subunit – ''Sulfolobus solfataricus''<br /> | ||
| - | **[[2au3]] – DNAP zinc-binding and RNA polymerase domains – ''Aquifex aeolicus''<br /> | ||
| - | **[[1v33]] - PhDNAP small subunit – ''Pyrocuccus horikoshii''<br /> | ||
| - | **[[1v34]] - PhDNAP small subunit + nucleotide<br /> | ||
| - | **[[1g71]] - PfDNAP small subunit<br /> | ||
| - | **[[1q57]] – T7DNAP/helicase (mutant) – Enterobacteria phage T7<br /> | ||
| - | **[[1nui]] – T7DNAP/helicase primase fragment (mutant)<br /> | ||
| - | **[[1cr0]] - T7DNAP/helicase helicase domain<br /> | ||
| - | **[[1cr1]], [[1cr2]], [[1cr4]] - T7DNAP/helicase helicase domain + nucleotide<br /> | ||
| - | **[[4e2k]] – SaDNAP – ''Staphylococcus aureus''<br /> | ||
| - | **[[2lzn]] – SaDNAP C terminal – NMR<br /> | ||
| - | **[[4edg]], [[4edk]], [[4edr]], [[4edt]], [[4edv]], [[4ee1]] – SaDNAP + nucleotide | ||
| - | |||
| - | *Bacterial primase | ||
| - | |||
| - | **[[2r6a]], [[2r6c]] - GsdnaG helicase binding domain + helicase – ''Geobacillus stearothermophilus''<br /> | ||
| - | **[[4m4w]] - GsdnaG helicase binding domain + helicase + DnaI<br /> | ||
| - | **[[1d0q]] - GsDNAP zinc-binding domain<br /> | ||
| - | **[[1z8s]] - GsdnaG dnaB binding domain - NMR<br /> | ||
| - | **[[2haj]] - EcdnaG catalytic domain - NMR<br /> | ||
| - | **[[3b39]] – EcdnaG catalytic domain + DNA<br /> | ||
| - | **[[1t3w]] – EcdnaG C-terminal<br /> | ||
| - | **[[1eqn]], [[1dd9]], [[1dde]] – EcdnaG catalytic core<br /> | ||
| - | |||
| - | *RNA polymerase from Bacteriophage T7 | ||
| - | |||
| - | **[[4rnp]] – T7RNAP<br /> | ||
| - | **[[1aro]] – T7RNAP + T7 lysozyme<br /> | ||
| - | **[[1cez]], [[1h38]], [[1qln]], [[2pi4]], [[2pi5]] - T7RNAP + DNA<br /> | ||
| - | **[[1msw]], [[1s0v]], [[1s76]], [[1s77]], [[3e2e]], [[3e3j]] - T7RNAP + DNA + RNA<br /> | ||
*Poly(A) RNA polymerase | *Poly(A) RNA polymerase | ||
Revision as of 10:04, 14 October 2015
RNA polymerase (RNAP, DNA primase, dnaG) catalyzes the addition of nucleotides to RNA during transcription.
DNA-dependent RNA polymerase catalyzes the transcription of RNA from a DNA template. The DNA-dependent eukaryote RNAP are divided to
RNAP I (or Pol I) which transcribes ribosomal RNA;
RNAP II (or Pol II) transcribes DNA and most snRNA and microRNA;
RNAP III (or Pol III) transcribes tRNA and 5S ribosomal RNA.
DNA primase (DNAP) is RNAP which catalyzes the synthesis of the RNA primer which complements an ssDNA template and initiates DNA synthesis.
dnaG is a bacterial primase.
For DNA-dependent RNA polymerase see
- Molecular Playground/T7 RNAP Conformations
- User:Luis E Ramirez-Tapia/T7 RNA polymerase
- Molecular Playground/T7 RNA Polymerase (7 mer int).
- Molecular Playground/Human mtRNA pol.
- Beta-Prime Subunit of Bacterial RNA Polymerase
RNA-dependent RNA polymerase catalyzes the replication of RNA from a RNA template. An example is the Influenza virus RNA polymerase which is composed of 3 subunits. Subunit PA is involved in cap-snatching. Subunit PB1 is involved in RNA synthesis. Subunit PB2 is involved in RNA replication and transcription. It is implicated in endonuclease cleavage of RNA primers. (1qln; blue: nontemplate strand; cyan: template strand; red:RNA). See also Transcription and RNA Processing.
For RNA-dependent RNA polymerase from Hepatitis C virus - NS5B - see
- NS5B.
- User:Michael Strong/H1N1/PB2
- User:Michael Strong/H1N1/PB2/MSA
- User:Michael Strong/H1N1/PA
- User:Michael Strong/H1N1/PA/MSA
Poly(A) RNA polymerase catalyzes the addition of long poly(A) tails to mRNA.
3D Structures of RNA polymerase
Updated on 14-October-2015
- Created with the participation of Craig T Martin.
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Karsten Theis
