Paxillin

Paxillin (PXN) is involved in actin membrane attachment at sites of cell adhesion to focal adhesion domains. PXN contains a number of domains which are involved in protein-protein interactions: LD, LIM, SH2 and SH3 binding sites. LD motifs are leucine-rich sequences which begin with leucine (L) and end with aspartate (D).

Function

PXN serves as a docking protein recruiting signaling molecules to focal adhesions.

Disease

PXN has enhanced expression in several types of cancer PXN mutations are associated with lung cancer tumor growth.

Relevance

Structural highlights

PXN LD motifs are localized on the N-terminal region while the LIM double zinc finger domains are found at the C-terminal.