6-phosphogluconate dehydrogenase

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'''6-phosphogluconate dehydrogenase''' (6PDH) catalyzes the decarboxylation reduction of 6-phosphogluconate (6PG) to ribulose 5-phosphate and CO2. This reaction is part of the pentose phosphate pathway. NADP is a cofactor in this reaction and is converted to NADPH.
 
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== Function ==
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'''6-phosphogluconate dehydrogenase''' (6PGD) catalyzes the decarboxylation reduction of 6-phosphogluconate (6PG) to ribulose 5-phosphate and CO2. This reaction is part of the pentose phosphate pathway. NADP is a cofactor in this reaction and is converted to NADPH.
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== Disease ==
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6PGD deficiency is an autosomal hereditary disease which manifests itself by abnormal breakdown of red blood cells. Treatment involves avoidance of drugs or foods which can cause hemolysis.
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== Relevance ==
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== Structural highlights ==
==3D structures of 6-phosphogluconate dehydrogenase==
==3D structures of 6-phosphogluconate dehydrogenase==
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*6PDH
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*6PGD
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**[[2pgd]] - s6PDH – sheep<BR />
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**[[2pgd]] - s6PGD – sheep<BR />
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**[[1pgj]] - 6PDH – ''Trypanosoma brucei''<BR />
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**[[1pgj]] - 6PGD – ''Trypanosoma brucei''<BR />
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**[[2p4q]] - 6PDH – yeast<BR />
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**[[2p4q]] - 6PGD – yeast<BR />
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**[[2zyg]] - 6PDH (mutant) – ''Klebsiella pneumonia''<BR />
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**[[2zyg]] - 6PGD (mutant) – ''Klebsiella pneumonia''<BR />
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**[[4e21]] - Gm6PDH – ''Geobacter metallireducens''
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**[[4e21]] - Gm6PGD – ''Geobacter metallireducens''
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**[[4gbj]] – Df6PDH – ''Dyadobacter fermentans''<br />
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**[[4gbj]] – Df6PGD – ''Dyadobacter fermentans''<br />
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**[[4gwg]] - h6PDH – human<br />
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**[[4gwg]] - h6PGD – human<br />
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*6PDH binary complex
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*6PGD binary complex
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**[[1pgn]] – s6PDH + Br-NADP<BR />
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**[[1pgn]] – s6PGD + Br-NADP<BR />
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**[[1pgo]] - s6PDH + NADP<BR />
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**[[1pgo]] - s6PGD + NADP<BR />
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**[[1pgp]] - s6PDH + 6PG<BR />
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**[[1pgp]] - s6PGD + 6PG<BR />
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**[[1pgq]] - s6PDH + AMP<BR />
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**[[1pgq]] - s6PGD + AMP<BR />
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**[[2jkv]] - h6PDH + NADP <BR />
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**[[2jkv]] - h6PGD + NADP <BR />
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**[[4gwk]] - h6PDH + 3PG<br />
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**[[4gwk]] - h6PGD + 3PG<br />
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**[[2zya]] - Ec6PDH (mutant) + 6PG – ''Escherichia coli''<BR />
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**[[2zya]] - Ec6PGD (mutant) + 6PG – ''Escherichia coli''<BR />
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**[[2w8z]], [[2w90]] - 6PDH + 6PG – ''Geobacillus stearothermophilus''<BR />
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**[[2w8z]], [[2w90]] - 6PGD + 6PG – ''Geobacillus stearothermophilus''<BR />
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**[[2iyo]] - Ll6PDH + 6PG – ''Lactococcus lactis''<BR />
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**[[2iyo]] - Ll6PGD + 6PG – ''Lactococcus lactis''<BR />
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**[[2zyd]] - Ec6PDH (mutant) + glucose
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**[[2zyd]] - Ec6PGD (mutant) + glucose
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*6PDH ternary complex
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*6PGD ternary complex
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**[[2iz1]] - Ll6PDH + inhibitor + ADP <BR />
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**[[2iz1]] - Ll6PGD + inhibitor + ADP <BR />
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**[[3fwn]] - Ec6PDH (mutant) + ADP + 6PG<br />
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**[[3fwn]] - Ec6PGD (mutant) + ADP + 6PG<br />
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**[[3pef]] – Gm6PDH (mutant) + NADP + monophosphoadenosine diphosphoribose<br />
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**[[3pef]] – Gm6PGD (mutant) + NADP + monophosphoadenosine diphosphoribose<br />
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**[[3w6u]] – Pc6PDH + NADP + monophosphoadenosine diphosphoribose – ''Pyrobaculum calidifontis''<br />
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**[[3w6u]] – Pc6PGD + NADP + monophosphoadenosine diphosphoribose – ''Pyrobaculum calidifontis''<br />
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**[[3w6z]] – Pc6PDH (mutant) + NADP + monophosphoadenosine diphosphoribose <br />
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**[[3w6z]] – Pc6PGD (mutant) + NADP + monophosphoadenosine diphosphoribose <br />
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*6PDH quaternary complex
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*6PGD quaternary complex
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**[[2iyp]] - Ll6PDH + ADP + ribulose 5-phosphate + NADP<BR />
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**[[2iyp]] - Ll6PGD + ADP + ribulose 5-phosphate + NADP<BR />
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**[[2iz0]] - Ll6PDH + inhibitor + ADP + NADP<BR />
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**[[2iz0]] - Ll6PGD + inhibitor + ADP + NADP<BR />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:59, 21 October 2015

Template:STRUCTURE 1pgj

Contents

Function

6-phosphogluconate dehydrogenase (6PGD) catalyzes the decarboxylation reduction of 6-phosphogluconate (6PG) to ribulose 5-phosphate and CO2. This reaction is part of the pentose phosphate pathway. NADP is a cofactor in this reaction and is converted to NADPH.

Disease

6PGD deficiency is an autosomal hereditary disease which manifests itself by abnormal breakdown of red blood cells. Treatment involves avoidance of drugs or foods which can cause hemolysis.

Relevance

Structural highlights

3D structures of 6-phosphogluconate dehydrogenase

Updated on 21-October-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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