A Disintegrin And Metalloproteinase
From Proteopedia
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{{STRUCTURE_2ao7| PDB=2ao7 | SIZE=350| SCENE=A_Disintegrin_And_Metalloproteinase/Cv/1 |right|CAPTION=A Disintegrin And Metalloproteinase complex with sulfate [[2ao7]] }} | {{STRUCTURE_2ao7| PDB=2ao7 | SIZE=350| SCENE=A_Disintegrin_And_Metalloproteinase/Cv/1 |right|CAPTION=A Disintegrin And Metalloproteinase complex with sulfate [[2ao7]] }} | ||
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[[A Disintegrin And Metalloproteinase]] (ADAM) are peptidases which cleave off extracellular portions of transmembrane proteins. ADAM inhibitors are used in anti-cancer therapy. ADAM family members are numbered. ADAM10 cleaves ephrin. ADAM13 details in [[Molecular Playground/ADAM13]]. ADAM17 (TACE) processes the tumor necrosis factor-α. ADAM33 is implicated in asthma. ADAMTS is ADAM with thrombospondin motifs. ADAMTS1 has anti-angionenic activity. ADAMTS4 and ADAMTS5 are involved in the degradation of aggrecan. ADAMTS13 cleaves von Willebrand factor involved in blood clotting. | [[A Disintegrin And Metalloproteinase]] (ADAM) are peptidases which cleave off extracellular portions of transmembrane proteins. ADAM inhibitors are used in anti-cancer therapy. ADAM family members are numbered. ADAM10 cleaves ephrin. ADAM13 details in [[Molecular Playground/ADAM13]]. ADAM17 (TACE) processes the tumor necrosis factor-α. ADAM33 is implicated in asthma. ADAMTS is ADAM with thrombospondin motifs. ADAMTS1 has anti-angionenic activity. ADAMTS4 and ADAMTS5 are involved in the degradation of aggrecan. ADAMTS13 cleaves von Willebrand factor involved in blood clotting. | ||
Revision as of 10:16, 21 October 2015
A Disintegrin And Metalloproteinase (ADAM) are peptidases which cleave off extracellular portions of transmembrane proteins. ADAM inhibitors are used in anti-cancer therapy. ADAM family members are numbered. ADAM10 cleaves ephrin. ADAM13 details in Molecular Playground/ADAM13. ADAM17 (TACE) processes the tumor necrosis factor-α. ADAM33 is implicated in asthma. ADAMTS is ADAM with thrombospondin motifs. ADAMTS1 has anti-angionenic activity. ADAMTS4 and ADAMTS5 are involved in the degradation of aggrecan. ADAMTS13 cleaves von Willebrand factor involved in blood clotting.
3D Structures of A Disintegrin And Metalloproteinase
Updated on 21-October-2015
