A Disintegrin And Metalloproteinase
From Proteopedia
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{{STRUCTURE_2ao7| PDB=2ao7 | SIZE=350| SCENE=A_Disintegrin_And_Metalloproteinase/Cv/1 |right|CAPTION=A Disintegrin And Metalloproteinase complex with sulfate [[2ao7]] }} | {{STRUCTURE_2ao7| PDB=2ao7 | SIZE=350| SCENE=A_Disintegrin_And_Metalloproteinase/Cv/1 |right|CAPTION=A Disintegrin And Metalloproteinase complex with sulfate [[2ao7]] }} | ||
| + | == Function == | ||
| - | [[A Disintegrin And Metalloproteinase]] (ADAM) are peptidases which cleave off extracellular portions of transmembrane proteins | + | [[A Disintegrin And Metalloproteinase]] (ADAM) are peptidases which cleave off extracellular portions of transmembrane proteins. ADAM family members are numbered.<br /> |
| + | * '''ADAM10''' cleaves ephrin.<br /> | ||
| + | * '''ADAM13''' details are in [[Molecular Playground/ADAM13]].<br /> | ||
| + | * '''ADAM17''' (TACE) processes the tumor necrosis factor-α.<br /> | ||
| + | * '''ADAM33''' is implicated in asthma.<br /> | ||
| + | * '''ADAMTS''' is ADAM with thrombospondin motifs. <br /> | ||
| + | * '''ADAMTS1''' has anti-angionenic activity. <br /> | ||
| + | * '''ADAMTS4''' and '''ADAMTS5''' are involved in the degradation of aggrecan.<br /> | ||
| + | * '''ADAMTS13''' cleaves von Willebrand factor involved in blood clotting. | ||
| - | + | == Disease == | |
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| + | ADAM inhibitors are used in anti-cancer therapy. ADAM33 is implicated in asthma. ADAMTS13 cleaves von Willebrand factor involved in blood clotting. | ||
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| + | == Relevance == | ||
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| + | == Structural highlights == | ||
== 3D Structures of A Disintegrin And Metalloproteinase == | == 3D Structures of A Disintegrin And Metalloproteinase == | ||
Revision as of 10:25, 21 October 2015
Contents |
Function
A Disintegrin And Metalloproteinase (ADAM) are peptidases which cleave off extracellular portions of transmembrane proteins. ADAM family members are numbered.
- ADAM10 cleaves ephrin.
- ADAM13 details are in Molecular Playground/ADAM13.
- ADAM17 (TACE) processes the tumor necrosis factor-α.
- ADAM33 is implicated in asthma.
- ADAMTS is ADAM with thrombospondin motifs.
- ADAMTS1 has anti-angionenic activity.
- ADAMTS4 and ADAMTS5 are involved in the degradation of aggrecan.
- ADAMTS13 cleaves von Willebrand factor involved in blood clotting.
Disease
ADAM inhibitors are used in anti-cancer therapy. ADAM33 is implicated in asthma. ADAMTS13 cleaves von Willebrand factor involved in blood clotting.
Relevance
Structural highlights
3D Structures of A Disintegrin And Metalloproteinase
Updated on 21-October-2015
