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5e26
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| - | ''' | + | ==Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate== |
| - | + | <StructureSection load='5e26' size='340' side='right' caption='[[5e26]], [[Resolution|resolution]] 2.14Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5e26]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E26 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PAU:PANTOTHENOIC+ACID'>PAU</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e26 OCA], [http://pdbe.org/5e26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e26 RCSB], [http://www.ebi.ac.uk/pdbsum/5e26 PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Disease == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/PANK2_HUMAN PANK2_HUMAN]] Atypical pantothenate kinase-associated neurodegeneration;Classic pantothenate kinase-associated neurodegeneration. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/PANK2_HUMAN PANK2_HUMAN]] May be the master regulator of the CoA biosynthesis. |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Pantothenate kinase]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: BROWN, P J]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
| - | [[Category: | + | [[Category: CHENG, C]] |
| - | [[Category: | + | [[Category: DONG, A]] |
| - | [[Category: | + | [[Category: Edwards, A M]] |
| - | [[Category: | + | [[Category: HONG, B S]] |
| - | [[Category: | + | [[Category: HUTCHINSON, A]] |
| - | [[Category: | + | [[Category: LOPPNAU, P]] |
| - | [[Category: Structural | + | [[Category: RAVICHANDRAN, M]] |
| + | [[Category: SEITOVA, A]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: TEMPEL, W]] | ||
| + | [[Category: Pank2]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 05:34, 22 October 2015
Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate
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Categories: Pantothenate kinase | Arrowsmith, C H | BROWN, P J | Bountra, C | CHENG, C | DONG, A | Edwards, A M | HONG, B S | HUTCHINSON, A | LOPPNAU, P | RAVICHANDRAN, M | SEITOVA, A | Structural genomic | TEMPEL, W | Pank2 | Sgc | Transferase
