5'-deoxy-5'-methylthioadenosine phosphorylase
From Proteopedia
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== Function == | == Function == | ||
| - | '''5’-deoxy-5’-methylthioadenosine phosphorylase''' (MTAP) catalyzes the reversible phosphorolysis of <scene name='59/595220/Cv/2'>5’-deoxy-5’-methylthioadenosine (MTA)</scene> to adenine and 5-methylthio-D-ribose-1-phosphate. | + | '''5’-deoxy-5’-methylthioadenosine phosphorylase''' (MTAP) catalyzes the reversible phosphorolysis of <scene name='59/595220/Cv/2'>5’-deoxy-5’-methylthioadenosine (MTA)</scene> to adenine and 5-methylthio-D-ribose-1-phosphate. <scene name='59/595220/Cv/3'>Click here to see active site</scene>. MTAP is part of the polyamine metabolism. This reaction is the principle source of adenine in human cells. MTAP catalyzes the first step in the methionine salvage pathway. |
== Disease == | == Disease == | ||
Revision as of 12:11, 22 October 2015
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3D structures of 5’-deoxy-5’-methylthioadenosine phosphorylase
Updated on 22-October-2015
