Antigen 85

(Difference between revisions)

Revision as of 07:06, 3 November 2015

Antigen 85C complex with detergent octylthioglucoside (PDB code 1va5)

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Updated on 03-November-2015

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-<StructureSection load='1f0p' size='340' side='right' caption='Antigen 85B complex with trehalose (stick model), MPD and MES (PDB code [[1f0p]])' scene=''>
+<StructureSection load='1va5' size='340' side='right' caption='Antigen 85C complex with detergent octylthioglucoside (PDB code [[1va5]])' scene=''>
-'''Antigens 85A, 85B and 85C''' posses mycolyltransferase activity and generate trehalose dimycolate which is an essential envelope lipid for ''Mycobacterium tuberculosis'' virulence.  Inhibition of these enzymes hinders growth of the bacteria.  The three enzymes show very high sequence identity (68-79%).  The 3D structures of the 3 antigens show that their active sites are virtually identical indicating that they share the same substrate.  However, residues at the surface of the enzymes are different.
 == Function ==
+'''Antigens 85A, 85B and 85C''' posses mycolyltransferase activity and generate trehalose dimycolate which is an essential envelope lipid for ''Mycobacterium tuberculosis'' virulence.  Inhibition of these enzymes hinders growth of the bacteria.  The three enzymes show very high sequence identity (68-79%).
 == Disease ==
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 == Structural highlights ==
+The 3D structures of the 3 antigens show that their active sites are virtually identical indicating that they share the same substrate.  However, residues at the surface of the enzymes are different.
 </StructureSection>