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Antithrombin

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{{STRUCTURE_3evj| PDB=3evj | SIZE=400| SCENE= |right|CAPTION=Antithrombin (beige) complex with thrombin heavy chain (pink), light chain (green) and heparin polysaccharide, [[1tb6]] }}
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<StructureSection load='3evj' size='340' side='right' caption='Tyrosine aminomutase complex with peptide-derived chromophore cofactor (PDB code [[2ohy]])' scene=''>
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<StructureSection load='3evj' size='340' side='right' caption='Glycosylated human antithrombin III complex with heparin (PDB code [[2ohy]])' scene=''>
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'''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interaction of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation. See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]].
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== Function ==
== Function ==
'''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. AT is relatively inactive until it binds the heparan sidechains of the microvasculature.<br />
'''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. AT is relatively inactive until it binds the heparan sidechains of the microvasculature.<br />
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▪ α-AT contains 4 occupied glycosylation sites and is found in blood palsma.<br />
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▪ '''α-AT''' contains 4 occupied glycosylation sites and is found in blood palsma.<br />
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▪ β-AT contains only 3 occupied glycosylation sites.<br />
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▪ '''β-AT''' contains only 3 occupied glycosylation sites.<br />
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▪ AT-I refers to the absorption of thrombin to fibrin.<br />
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▪ '''AT-I''' refers to the absorption of thrombin to fibrin.<br />
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▪ AT-II and heparin interfere with the interaction of thrombin and fibrinogen.<br />
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▪ '''AT-II''' and heparin interfere with the interaction of thrombin and fibrinogen.<br />
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▪ AT-III inactivates thrombin in plasma.<br />
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▪ '''AT-III''' inactivates thrombin in plasma.<br />
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▪ AT-IV becomes activated during blood coagulation.<br />
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▪ '''AT-IV''' becomes activated during blood coagulation.<br />
See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]].
See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]].

Revision as of 09:28, 3 November 2015

Glycosylated human antithrombin III complex with heparin (PDB code 2ohy)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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