Arginine repressor
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | <StructureSection load=' | + | <StructureSection load='1xxb' size='350' side='right' caption='Structure of arginine repressor hexamer complex with DNA and arginine (PDB entry [[3laj]])' scene=''> |
| + | |||
| + | == Function == | ||
| - | '''Arginine repressor''' (ArgR) is a prokaryotic repressor which regulates the arginine deiminase pathway. In this pathway, arginine is metabolized to form ammonia, CO2 and ATP. The ArgR releases the expression of the arginine deiminase pathway in the presence of arginine. The genes controlled by ArgR are not found in a single operon. While repressors are usually active as dimers, ArgR is a hexamer and binds to 2 palindromic DNA sites. The structure of ArgR shows a DNA-binding domain at the N-terminal and a C-terminal domain which contains the intersubunit interaction sites and the Arg binding site. | + | '''Arginine repressor''' (ArgR) is a prokaryotic repressor which regulates the arginine deiminase pathway. In this pathway, arginine is metabolized to form ammonia, CO2 and ATP. The ArgR releases the expression of the arginine deiminase pathway in the presence of arginine. The genes controlled by ArgR are not found in a single operon. While repressors are usually active as dimers, ArgR is a hexamer and binds to 2 palindromic DNA sites. |
| + | |||
| + | == Structural highlights == | ||
| + | |||
| + | The structure of ArgR shows a DNA-binding domain at the acidic N-terminal and a basic C-terminal domain which contains the intersubunit interaction sites and the Arg binding site. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:03, 4 November 2015
| |||||||||||
3D structures of arginine repressor
Updated on 04-November-2015
