Arginine repressor

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<StructureSection load='1xxb' size='350' side='right' caption='Structure of arginine repressor hexamer complex with DNA and arginine (PDB entry [[3laj]])' scene=''>
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<StructureSection load='1xxb' size='350' side='right' caption='E. coli structure of arginine repressor C terminal hexamer complex with arginine (PDB entry [[1xxb]])' scene=''>
== Function ==
== Function ==
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'''Arginine repressor''' (ArgR) is a prokaryotic repressor which regulates the arginine deiminase pathway. In this pathway, arginine is metabolized to form ammonia, CO2 and ATP. The ArgR releases the expression of the arginine deiminase pathway in the presence of arginine. The genes controlled by ArgR are not found in a single operon. While repressors are usually active as dimers, ArgR is a hexamer and binds to 2 palindromic DNA sites.
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'''Arginine repressor''' (ArgR) is a prokaryotic repressor which regulates the arginine deiminase pathway. In this pathway, arginine is metabolized to form ammonia, CO2 and ATP. The ArgR releases the expression of the arginine deiminase pathway in the presence of arginine. The genes controlled by ArgR are not found in a single operon. While repressors are usually active as dimers, ArgR is a hexamer and binds to 2 palindromic DNA sites called ARG box in its N terminal domain.
== Structural highlights ==
== Structural highlights ==

Revision as of 10:06, 4 November 2015

E. coli structure of arginine repressor C terminal hexamer complex with arginine (PDB entry 1xxb)

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3D structures of arginine repressor

Updated on 04-November-2015

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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