Arylamine N-acetyltransferase

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Revision as of 11:53, 4 November 2015 (edit) Michal Harel (Talk | contribs) ← Previous diff		Revision as of 12:04, 4 November 2015 (edit) (undo) Michal Harel (Talk | contribs) Next diff →
Line 27:		Line 27:
	**[[4nv8]] – RlNAT (mutant)<br />		**[[4nv8]] – RlNAT (mutant)<br />
	**[[2ija]] – hNAT1 (mutant) – human<br />		**[[2ija]] – hNAT1 (mutant) – human<br />
-	**[[2pqt]] - hNAT1<br />
-	**[[2pfr]] – hNAT2<br />
	**[[1w4t]] – NAT – ''Pseudomonas aeruginosa''<br />		**[[1w4t]] – NAT – ''Pseudomonas aeruginosa''<br />
	**[[3d9w]] – NAT – ''Nocardia farcinica''<br />		**[[3d9w]] – NAT – ''Nocardia farcinica''<br />
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	*Arylamine N-acetyltransferase binary complex		*Arylamine N-acetyltransferase binary complex
		+	**[[2pqt]] - hNAT1 + Cys intermediate<br />
		+	**[[2pfr]] – hNAT2 + CoA<br />
	**[[2vfc]] – MmNAT + CoA<br />		**[[2vfc]] – MmNAT + CoA<br />
	**[[3ltw]] – MmNAT + hydralazine<br />		**[[3ltw]] – MmNAT + hydralazine<br />

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Revision as of 12:04, 4 November 2015

Template:STRUCTURE 3ltw

Function

Arylamine N-acetyltransferase (NAT) catalyzes the transfer of an acetyl group from acetyl-CoA to an arylamine.

Relevance

Acetylation is a major route of biotransformation for many arylamines and hydrazine drugs and known carcinogens like cigarette smoke. The levels of NAT in the body has important consequences with regard to an individual’s susceptibility to certain drug-induced toxicities and cancer.

3D structures of arylamine N-acetyltransferase

Updated on 04-November-2015