Arylamine N-acetyltransferase
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{ | + | {{STRUCTURE_2pfr| PDB=2pfr | SIZE=400| SCENE= |right|CAPTION=Arylamine N-acetyltransferase complex with hydrazinophthalazine and formate [[3ltw]] }} |
<!-- | <!-- | ||
Revision as of 07:38, 5 November 2015
Function
Arylamine N-acetyltransferase (NAT) catalyzes the transfer of an acetyl group from acetyl-CoA to an arylamine.
Relevance
Acetylation is a major route of biotransformation for many arylamines and hydrazine drugs and known carcinogens like cigarette smoke. The levels of NAT in the body has important consequences with regard to an individual’s susceptibility to certain drug-induced toxicities and cancer.
3D structures of arylamine N-acetyltransferase
Updated on 05-November-2015
