Arylamine N-acetyltransferase
From Proteopedia
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{{STRUCTURE_2pfr| PDB=2pfr | SIZE=400| SCENE= |right|CAPTION=Arylamine N-acetyltransferase complex with hydrazinophthalazine and formate [[3ltw]] }} | {{STRUCTURE_2pfr| PDB=2pfr | SIZE=400| SCENE= |right|CAPTION=Arylamine N-acetyltransferase complex with hydrazinophthalazine and formate [[3ltw]] }} | ||
| - | + | <StructureSection load='2pfr' size='340' side='right' caption='Human arylamine N-acetyltransferase 2 complex CoA (PDB code [[2pfr]])' scene=''> | |
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Acetylation is a major route of biotransformation for many arylamines and hydrazine drugs and known carcinogens like cigarette smoke. The levels of NAT in the body has important consequences with regard to an individual’s susceptibility to certain drug-induced toxicities and cancer. | Acetylation is a major route of biotransformation for many arylamines and hydrazine drugs and known carcinogens like cigarette smoke. The levels of NAT in the body has important consequences with regard to an individual’s susceptibility to certain drug-induced toxicities and cancer. | ||
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| + | == Structural highlights == | ||
==3D structures of arylamine N-acetyltransferase== | ==3D structures of arylamine N-acetyltransferase== | ||
Revision as of 07:41, 5 November 2015
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