Arylamine N-acetyltransferase
From Proteopedia
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| - | <StructureSection load='2pfr' size='340' side='right' caption='Human arylamine N-acetyltransferase 2 complex CoA (PDB code [[2pfr]])' scene=''> | + | <StructureSection load='2pfr' size='340' side='right' caption='Human arylamine N-acetyltransferase 2 complex with CoA, sulfate and unknown atom (PDB code [[2pfr]])' scene=''> |
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Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page. | Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page. | ||
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== Function == | == Function == | ||
| - | '''Arylamine N-acetyltransferase''' (NAT) catalyzes the transfer of an acetyl group from acetyl-CoA to an arylamine. | + | '''Arylamine N-acetyltransferase''' (NAT) catalyzes the transfer of an acetyl group from acetyl-CoA to an arylamine. Human NAT have 2 polymorphs with different substrate specificities. '''NAT1''' acetylates p-aminisalycilates while '''NAT2''' acetylates hydralazine. |
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| + | == Disease == | ||
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| + | Human NAT1 is overexpressed in some kinds of breast cancer. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
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| + | NAT acetylates using a catalytic Cys-His-Asp triad. | ||
==3D structures of arylamine N-acetyltransferase== | ==3D structures of arylamine N-acetyltransferase== | ||
Revision as of 07:59, 5 November 2015
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