Annexin

Function

Annexins are proteins which make a membrane scaffold. They bind negatively charged phospholipids and contain a 70 amino acid long annexin repeat. Annexins divide into species and are numbered from I to XII. Annexin V is the most abundant scaffolding protein. Annexin E1 (AnE1) is associated with tubulin in trophozoites of Giardia lamblia and forms local slubs in the flagella. Annexin A-V has a major role in coagulation. Annexin AII has a major role in fibrinolysis. Annexins bind phospholipids and Ca+2 ions.

Relevance

Annexin I is involved in anti-inflammatory responses and apoptotic mechanisms.

Structural highlights

Annexins consist of 2 domains - the C-terminal core and the N-terminal head. The core domain consists of 4 annexin repeats containing 5 helices. The core domain concave side contains the Ca+2 binding sites.

3D structures of annexin

Updated on 11-November-2015