Calcium/Calmodulin-dependent protein kinase
From Proteopedia
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*'''CaMKIII''' phosphorylates eukaryotic elongation factor 2. <br /> | *'''CaMKIII''' phosphorylates eukaryotic elongation factor 2. <br /> | ||
*'''CASK''' is a membrane associated CaMK.<br /> | *'''CASK''' is a membrane associated CaMK.<br /> | ||
| - | *'''DAPK''' is a death-associated CaMK which protects cells from some programmed cell death. | + | *'''DAPK''' is a death-associated CaMK which protects cells from some programmed cell death. <br /> |
| + | For details see [[Calcium-dependent protein kinase]]. | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 11:35, 15 November 2015
Contents |
Function
Ca2+/Calmodulin dependent protein kinase (CaMK) are activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr.
- CaMKI is a specialized CaM kinase.
- CaMKII is multifunctional kinase.
- CaMKIII phosphorylates eukaryotic elongation factor 2.
- CASK is a membrane associated CaMK.
- DAPK is a death-associated CaMK which protects cells from some programmed cell death.
For details see Calcium-dependent protein kinase.
Structural highlights
CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). DAPK contains a regulatory (RD) and autoinhibitory (AD) domains.
3D Structures of Ca2+/Calmodulin dependent protein kinase
Updated on 15-November-2015
See also
Calcium-dependent protein kinase, a member of the CaM kinase family
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Alice Harmon, Jaime Prilusky
