Gunnar Reiske/Sandbox 102

From Proteopedia

(Difference between revisions)

Revision as of 21:45, 15 November 2015

How Gluten Protein Structure Stimulates an Immune Response

"Prolyl endopeptidases (PEPs) are a unique class of serine proteases with considerable therapeutic potential for the treatment of celiac sprue." (2005) Proc.Natl.Acad.Sci.USA 102: 3599-3604 (pubmed?) (PDB code 1yr2)

Drag the structure with the mouse to rotate

The protein, gluten is found in wheat and grains such as rye and barley. Gluten is also involved with inducing an inflammatory response in individuals with celiac disease. Individuals who have the disease cannot digest gluten due to the protein’s structure, which will damage the small intestine. In detail, if an individual with celiac disease ingests foods containing gluten, the immune system responds by damaging the villi, which are fingerlike projections lining the small intestine. This type of immune response denies the body’s ability to absorb nutrients that pass through the small intestine and into the bloodstream. As a result of the damaged villi, people with celiac disease can become malnourished. Although celiac disease is genetic, the question of how the protein triggers an immune response in the gastrointestinal tract of affected individuals was further explored.

Gluten is a protein complex comprised of gliadin and glutenin. Gliadins, for those with celiac disease, are the principle toxic component of gluten and are composed of proline and glutamine peptide sequences. The peptides enter the circulatory system and come into contact with lymphocytes and T cells, resulting in the release of inflammatory chemicals. The inflammatory chemicals interact with the villi of the small intestine and damage them, disabling the body from nutrient absorption. The symptoms can include abdominal pain, weight loss, fatigue, and many other symptoms associated with malnutrition. As of now, the only treatment for celiac disease is the total exclusion of gluten from the person’s diet.

You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

1 Function
2 Disease
3 Relevance
4 Structural highlights
5 Gluten Complex
6 HLA-DQ2
7 HLA-DQ8
8 1yr2(placeholder)
9 2bkl(placeholder)

Function

Disease

Relevance

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Gluten Complex

HLA-DQ2

HLA-DQ8

1yr2(placeholder)

2bkl(placeholder)

References

↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

Proteopedia Page Contributors and Editors (what is this?)

Ben Horansky, Devin Joseph, Premal Patel, Gunnar Reiske, Katlin Cannon

Retrieved from "http://52.214.119.220/wiki/index.php/Gunnar_Reiske/Sandbox_102"

@@ Line 17: / Line 17: @@
 This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+== Gluten Complex ==
+== HLA-DQ2 ==
+== HLA-DQ8 ==
+== 1yr2(placeholder) ==
+== 2bkl(placeholder) ==
 </StructureSection>
 == References ==
 <references/>