Calcium/Calmodulin-dependent protein kinase

Function

Ca2+/Calmodulin dependent protein kinase (CaMK) are activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr.

• CaMKI is a specialized CaM kinase.
  
• CaMKII is multifunctional kinase.
  
• CaMKIII phosphorylates eukaryotic elongation factor 2.
  
• CASK is a membrane associated CaMK.
  
• DAPK is a death-associated CaMK which protects cells from some programmed cell death.
  

For details see Calcium-dependent protein kinase.

Structural highlights

CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). DAPK contains a regulatory (RD) and autoinhibitory (AD) domains. The activity of human CamKII is regulated by autophosphorylation of Thr 286 and Thr 305.