Blue copper oxidase CueO

Function

Blue copper oxidase CueO (CueO) is an E. coli enzyme which catalyzes the conversion of Cu+1 to Cu+2 resulting in the detoxification of copper by the prevention of its uptake into the cytoplasm.

Relevance

CueO is involved in prevention of oxidative damage in the periplasm.

Structural highlights

The Cu moieties are coordinated by at least 2 histidine residues: , .^[1]

3D structures of blue copper oxidase CueO

Updated on 16-November-2015

3nsf – EcCueO – Escherichia coli

3nt0 – EcCueO (mutant) + Cu+1
3od3, 3pav, 4e9q, 4e9r, 4e9s, 4e9t, 4ef3, 4ner – EcCueO + Cu+2
3nsc, 3nsd, 3uaa, 3uab, 3uac, 3uad, 3uae, 4hak, 4hal – EcCueO (mutant) + Cu+2
3qqx – EcCueO (mutant) + Cu+2 + Cu+1
1n68 – EcCueO + Cu+2 + Cu-Cl-Cu
1pf3 – EcCueO (mutant) + Cu+2 + Cu-Cl-Cu
2fqd, 2fqe, 2fqf, 2fqg, 3pau – EcCueO + Cu+2 + Cu-O-Cu
2yxv, 2yxw, 3nsy – EcCueO (mutant) + Cu+2 + Cu-O-Cu

References

1. ↑ Li X, Wei Z, Zhang M, Peng X, Yu G, Teng M, Gong W. Crystal structures of E. coli laccase CueO at different copper concentrations. Biochem Biophys Res Commun. 2007 Mar 2;354(1):21-6. Epub 2006 Dec 22. PMID:17217912 doi:10.1016/j.bbrc.2006.12.116