Function
Blue copper oxidase CueO (CueO) is an E. coli enzyme which catalyzes the conversion of Cu+1 to Cu+2 resulting in the detoxification of copper by the prevention of its uptake into the cytoplasm.[1]
Relevance
CueO is involved in prevention of oxidative damage in the periplasm.
Structural highlights
The Cu moieties are coordinated by at least 2 histidine residues: , .[2]
3D structures of blue copper oxidase CueO
Updated on 18-November-2015
3nsf – EcCueO – Escherichia coli
3nt0 – EcCueO (mutant) + Cu+1
3od3, 3pav, 4e9q, 4e9r, 4e9s, 4e9t, 4ef3, 4ner – EcCueO + Cu+2
3nsc, 3nsd, 3uaa, 3uab, 3uac, 3uad, 3uae, 4hak, 4hal – EcCueO (mutant) + Cu+2
3qqx – EcCueO (mutant) + Cu+2 + Cu+1
1n68 – EcCueO + Cu+2 + Cu-Cl-Cu
1pf3 – EcCueO (mutant) + Cu+2 + Cu-Cl-Cu
2fqd, 2fqe, 2fqf, 2fqg, 3pau – EcCueO + Cu+2 + Cu-O-Cu
2yxv, 2yxw, 3nsy – EcCueO (mutant) + Cu+2 + Cu-O-Cu
References
- ↑ Grass G, Rensing C. CueO is a multi-copper oxidase that confers copper tolerance in Escherichia coli. Biochem Biophys Res Commun. 2001 Sep 7;286(5):902-8. PMID:11527384 doi:http://dx.doi.org/10.1006/bbrc.2001.5474
- ↑ Li X, Wei Z, Zhang M, Peng X, Yu G, Teng M, Gong W. Crystal structures of E. coli laccase CueO at different copper concentrations. Biochem Biophys Res Commun. 2007 Mar 2;354(1):21-6. Epub 2006 Dec 22. PMID:17217912 doi:10.1016/j.bbrc.2006.12.116
