Casein kinase

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{{STRUCTURE_3mb6| PDB=3mb6 | SIZE=400| SCENE= |right|CAPTION=Human casein kinase catalytic subunit complex with difurane derivative inhibitor and sulfate ion, [[3mb6]] }}
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{{STRUCTURE_4g16| PDB=4g16 | SIZE=400| SCENE= |right|CAPTION=Human casein kinase catalytic subunit complex with difurane derivative inhibitor and sulfate ion, [[3mb6]] }}
== Function ==
== Function ==

Revision as of 10:39, 19 November 2015

Template:STRUCTURE 4g16

Function

Casein kinase (CK) is a protein kinase which functions as regulator of signal transduction.

  • CK1 is a serine/threonine kinase with several members: α, β1, γ1, γ2, γ3, δ and ε.
  • CK2 functions in cell cycle control, DNA repair and circadian rhythm regulation.

Structural highlights

CK2 is a tetramer with a pair of 2 subunits – the α subunit is the catalytic one and the β subunit is the regulatory one.

3D Structures of casein kinase

Updated on 19-November-2015

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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