Carbonyl reductase
From Proteopedia
(Difference between revisions)
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'''Carbonyl reductase''' (CBR) catalyzes the reaction converting R-CHOH-R and NADP to R-CO-R’ and NADPH. CBR has wide substrate specificity oxidoreductase activity. CBR has similar properties to aldose reductase and aldehyde reductase. (R)-specific carbonyl reductase cofactor is Zn+2 ion. | '''Carbonyl reductase''' (CBR) catalyzes the reaction converting R-CHOH-R and NADP to R-CO-R’ and NADPH. CBR has wide substrate specificity oxidoreductase activity. CBR has similar properties to aldose reductase and aldehyde reductase. (R)-specific carbonyl reductase cofactor is Zn+2 ion. | ||
| - | *<scene name='48/489333/Cv/2'>Active site</scene> of Mouse carbonyl reductase ([[1cyd]]). | + | *<scene name='48/489333/Cv/2'>Active site</scene> of Mouse carbonyl reductase ([[1cyd]]).<ref>PMID:8805511</ref> |
</StructureSection> | </StructureSection> | ||
==3D structures of carbonyl reductase== | ==3D structures of carbonyl reductase== | ||
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**[[3bhm]] - hCBR1 + hydroxymethylglutathione + NADPH<BR /> | **[[3bhm]] - hCBR1 + hydroxymethylglutathione + NADPH<BR /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 13:22, 19 November 2015
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3D structures of carbonyl reductase
Updated on 19-November-2015
References
- ↑ Tanaka N, Nonaka T, Nakanishi M, Deyashiki Y, Hara A, Mitsui Y. Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family. Structure. 1996 Jan 15;4(1):33-45. PMID:8805511
