4qkd
From Proteopedia
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== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/ALKB7_HUMAN ALKB7_HUMAN]] Probable dioxygenase required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death <ref name="death">PMID: | + | [[http://www.uniprot.org/uniprot/ALKB7_HUMAN ALKB7_HUMAN]] Probable dioxygenase required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death <ref name="death">PMID:23572141</ref>. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism.<ref>PMID:23666923</ref> |
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== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 21:24, 22 November 2015
Crystal structure of human ALKBH7 in complex with alpha-ketoglutarate and Mn(II)
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