Cathepsin
From Proteopedia
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<StructureSection load='1pbh' size='450' side='right' scene='42/421669/Cv/2' caption='human procathepsin B, [[1pbh]]'> | <StructureSection load='1pbh' size='450' side='right' scene='42/421669/Cv/2' caption='human procathepsin B, [[1pbh]]'> | ||
| + | == Function == | ||
[[Cathepsin]] (CTS) is a protease which becomes activated at low pH. It is found in lysosomes. Members of the CTS group are denoted as CTSA, CTSB etc and cleave proteins at different peptide bonds. The CTSs are expressed as an inactive precursor pro-CTS (PCTS) which becomes active when a long residue prosegment is cleaved off producing the mature CTS (MCTS).<ref>PMID:15751268</ref> | [[Cathepsin]] (CTS) is a protease which becomes activated at low pH. It is found in lysosomes. Members of the CTS group are denoted as CTSA, CTSB etc and cleave proteins at different peptide bonds. The CTSs are expressed as an inactive precursor pro-CTS (PCTS) which becomes active when a long residue prosegment is cleaved off producing the mature CTS (MCTS).<ref>PMID:15751268</ref> | ||
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| + | ==Disease == | ||
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| + | CTS B overexpression is associated with metastatic phenotypes in cancer. | ||
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| + | == Structural highlights == | ||
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| + | CTS B is a cysteine protease. The active site contains a cysteine residue from the N-terminal domain and His residue from the C-terminal domain. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Cathepsin == | == 3D Structures of Cathepsin == | ||
Revision as of 11:10, 23 November 2015
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3D Structures of Cathepsin
Updated on 23-November-2015
References
- ↑ Nomura T, Katunuma N. Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells. J Med Invest. 2005 Feb;52(1-2):1-9. PMID:15751268
