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CD2-associated protein

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<StructureSection load='2j6o' size='450' side='right' caption='Structure of human CD2AP SH3 domain 1 (green) complex with E3 ubiquitin ligase peptide (deeppink) (PDB entry [[2j6o]])' scene='56/569738/Cv/1'>
<StructureSection load='2j6o' size='450' side='right' caption='Structure of human CD2AP SH3 domain 1 (green) complex with E3 ubiquitin ligase peptide (deeppink) (PDB entry [[2j6o]])' scene='56/569738/Cv/1'>
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== Function ==
'''CD2-associated protein''' (CD2AP) called also '''CMS''', is a scaffolding protein which regulates actin cytoskeleton. CD2AP SH3 domain interacts with actin and a variety of membrane proteins. CD2AP contains in its N-terminal 3 SH3 domains followed by a proline-rich region.<ref>PMID:12354621</ref><ref>PMID:17020880</ref>
'''CD2-associated protein''' (CD2AP) called also '''CMS''', is a scaffolding protein which regulates actin cytoskeleton. CD2AP SH3 domain interacts with actin and a variety of membrane proteins. CD2AP contains in its N-terminal 3 SH3 domains followed by a proline-rich region.<ref>PMID:12354621</ref><ref>PMID:17020880</ref>
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== Disease ==
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Haploinsufficiency of CD2AP is associated with susceptibility of glomerular disease
</StructureSection>
</StructureSection>

Revision as of 09:36, 24 November 2015

Structure of human CD2AP SH3 domain 1 (green) complex with E3 ubiquitin ligase peptide (deeppink) (PDB entry 2j6o)

Drag the structure with the mouse to rotate

3D structures of CD2-associated protein

Updated on 24-November-2015

References

  1. ↑ Dikic I. CIN85/CMS family of adaptor molecules. FEBS Lett. 2002 Oct 2;529(1):110-5. PMID:12354621
  2. ↑ Moncalian G, Cardenes N, Deribe YL, Spinola-Amilibia M, Dikic I, Bravo J. Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain. J Biol Chem. 2006 Dec 15;281(50):38845-53. Epub 2006 Oct 3. PMID:17020880 doi:10.1074/jbc.M606411200

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Michal Harel, Alexander Berchansky

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