Cephalosporin acylase
From Proteopedia
(Difference between revisions)
| Line 12: | Line 12: | ||
**[[2nlz]] - CSA – ''Bacillus halodurans''<br /> | **[[2nlz]] - CSA – ''Bacillus halodurans''<br /> | ||
**[[1fm2]] - BdCSA – ''Brevundimonas diminuta''<br /> | **[[1fm2]] - BdCSA – ''Brevundimonas diminuta''<br /> | ||
| - | **[[1gk0]], [[1gk1]], [[1ghd]] - PsCSA – ''Pseudomonas''<br /> | + | **[[1gk0]], [[1gk1]], [[1ghd]], [[4hsr]], [[4hst]] - PsCSA – ''Pseudomonas''<br /> |
| - | **[[2ae3]], [[2ae5]] - PsCSA α + β (mutant) subunits<br /> | + | **[[2ae3]], [[2ae5]], [[3jtq]], [[2adv]] - PsCSA α + β (mutant) subunits<br /> |
| - | **[[2ae4]], [[4e55]], [[4e56]], [[4e57]] - PsCSA α (mutant) + β subunits<br /> | + | **[[2ae4]], [[4e55]], [[4e56]], [[4e57]], [[3jtr]] - PsCSA α (mutant) + β subunits<br /> |
**[[1keh]] - BdCSA precursor (mutant) | **[[1keh]] - BdCSA precursor (mutant) | ||
Revision as of 10:21, 26 November 2015
Template:STRUCTURE 1jvz
Cephalosporin acylase (CSA) catalyzes the conversion of cephalosporin C (CPC) to 7-amino-cephalosporanic acid (7-ACA). CSA contains 2 non-identical subunits. CSA is used commercially for production of semi-synthetic cephalosporin antibiotics. The active site pocket of CSA is similar to that of penicillin acylase. CSA precursor is cleaved at 2 sites forming the active heterodimer.
3D structures of cephalosporin acylase
Updated on 26-November-2015
