CD59
From Proteopedia
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<StructureSection load='4bik' size='350' side='right' caption='Structure of human CD59 extracellular domain (green and yellow) complex with intermedilysin (grey and pink) (PDB entry [[4bik]])' scene=''> | <StructureSection load='4bik' size='350' side='right' caption='Structure of human CD59 extracellular domain (green and yellow) complex with intermedilysin (grey and pink) (PDB entry [[4bik]])' scene=''> | ||
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== Function == | == Function == | ||
Revision as of 09:09, 29 November 2015
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Contents |
Function
CD59 (Cluster of Differentiation 59) is a protein which attaches to host cells via a GPI anchor. CD59 can prevent the formation of complement membrane attack complex via binding to complement C8 or C9.
Relevance
HIV, vaccinia and cytomegalovirus incorporate human CD59 into their envelope thus preventing their lysis by complement.
Disease
Mutations in CD59 causes disease involving thrombosis.
3D structures of CD59
Updated on 29-November-2015
1erg, 1erh, 1cdq, 1cdr, 1cds – hCD59 extracellular domain – human - NMR
2ofs, 2j8b, 2uwr, 2ux2 – hCD59 extracellular domain
4bik – hCD59 extracellular domain + intermedilysin
