CD59

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== Function ==
== Function ==
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'''CD59''' ('''Cluster of Differentiation 59''') is a protein which attaches to host cells via a GPI anchor. CD59 can prevent the formation of complement membrane attack complex via binding to complement C8 or C9.
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'''CD59''' ('''Cluster of Differentiation 59''') is a protein which attaches to host cells via a GPI anchor. CD59 can prevent the formation of complement membrane attack complex via binding to complement C8 or C9. <ref>PMID:1698710</ref>
== Relevance ==
== Relevance ==

Revision as of 11:58, 29 November 2015

Structure of human CD59 extracellular domain (green) complex with intermedilysin (cyan) (PDB entry 4bik)

Drag the structure with the mouse to rotate

3D structures of CD59

Updated on 29-November-2015

1erg, 1erh, 1cdq, 1cdr, 1cds – hCD59 extracellular domain – human - NMR
2ofs, 2j8b, 2uwr, 2ux2 – hCD59 extracellular domain
4bik – hCD59 extracellular domain + intermedilysin

References

  1. ↑ Meri S, Morgan BP, Davies A, Daniels RH, Olavesen MG, Waldmann H, Lachmann PJ. Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers. Immunology. 1990 Sep;71(1):1-9. PMID:1698710
  2. ↑ Johnson S, Brooks NJ, Smith RA, Lea SM, Bubeck D. Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59. Cell Rep. 2013 May 30;3(5):1369-77. doi: 10.1016/j.celrep.2013.04.029. Epub 2013 , May 9. PMID:23665225 doi:10.1016/j.celrep.2013.04.029

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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