2z6h
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00020 ARM], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00185 ARM]</span> | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6h OCA], [http://www.ebi.ac.uk/pdbsum/2z6h PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2z6h RCSB]</span> | ||
}} | }} | ||
'''Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain''' | '''Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain''' | ||
| + | |||
| + | ==Overview== | ||
| + | beta-catenin plays essential roles in cell adhesion and Wnt signaling, while deregulation of beta-catenin is associated with multiple diseases including cancers. Here, we report the crystal structures of full-length zebrafish beta-catenin and a human beta-catenin fragment that contains both the armadillo repeat and the C-terminal domains. Our structures reveal that the N-terminal region of the C-terminal domain, a key component of the C-terminal transactivation domain, forms a long alpha helix that packs on the C-terminal end of the armadillo repeat domain, and thus forms part of the beta-catenin superhelical core. The existence of this helix redefines our view of interactions of beta-catenin with some of its critical partners, including ICAT and Chibby, which may form extensive interactions with this C-terminal domain alpha helix. Our crystallographic and NMR studies also suggest that the unstructured N-terminal and C-terminal tails interact with the ordered armadillo repeat domain in a dynamic and variable manner. | ||
==About this Structure== | ==About this Structure== | ||
2Z6H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6H OCA]. | 2Z6H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6H OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | Crystal Structure of a Full-Length beta-Catenin., Xing Y, Takemaru K, Liu J, Berndt JD, Zheng JJ, Moon RT, Xu W, Structure. 2008 Mar;16(3):478-87. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18334222 18334222] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Liu, J.]] | [[Category: Liu, J.]] | ||
[[Category: Moon, R.]] | [[Category: Moon, R.]] | ||
| - | [[Category: Takemaru, K | + | [[Category: Takemaru, K.]] |
[[Category: Xing, Y.]] | [[Category: Xing, Y.]] | ||
[[Category: Xu, W.]] | [[Category: Xu, W.]] | ||
| Line 40: | Line 48: | ||
[[Category: wnt signaling pathway]] | [[Category: wnt signaling pathway]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 10:03:19 2008'' |
Revision as of 08:03, 26 March 2008
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| , resolution 2.20Å | |||||||
|---|---|---|---|---|---|---|---|
| Domains: | ARM, ARM | ||||||
| Resources: | FirstGlance, OCA, PDBsum, JenaLib, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain
Overview
beta-catenin plays essential roles in cell adhesion and Wnt signaling, while deregulation of beta-catenin is associated with multiple diseases including cancers. Here, we report the crystal structures of full-length zebrafish beta-catenin and a human beta-catenin fragment that contains both the armadillo repeat and the C-terminal domains. Our structures reveal that the N-terminal region of the C-terminal domain, a key component of the C-terminal transactivation domain, forms a long alpha helix that packs on the C-terminal end of the armadillo repeat domain, and thus forms part of the beta-catenin superhelical core. The existence of this helix redefines our view of interactions of beta-catenin with some of its critical partners, including ICAT and Chibby, which may form extensive interactions with this C-terminal domain alpha helix. Our crystallographic and NMR studies also suggest that the unstructured N-terminal and C-terminal tails interact with the ordered armadillo repeat domain in a dynamic and variable manner.
About this Structure
2Z6H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal Structure of a Full-Length beta-Catenin., Xing Y, Takemaru K, Liu J, Berndt JD, Zheng JJ, Moon RT, Xu W, Structure. 2008 Mar;16(3):478-87. PMID:18334222
Page seeded by OCA on Wed Mar 26 10:03:19 2008
Categories: Homo sapiens | Single protein | Liu, J. | Moon, R. | Takemaru, K. | Xing, Y. | Xu, W. | Zheng, J. | Activator | Alternative splicing | Beta-catenin | C-terminal domain | Cell adhesion | Crystal structure | Cytoplasm | Cytoskeleton | Disease mutation | Nucleus | Phosphorylation | Polymorphism | Structural protein | Transcription | Transcription regulation | Ubl conjugation | Wnt signaling pathway
