Cellobiohydrolase

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== Function ==
== Function ==
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'''Cellobiohydrolase''' (CBH) is a cellulase which degrades cellulose by hydrolysing the 1,4-β-D-glycosidic bonds. CBH is an exocellulase which cleaves two to four units from the ends of cellulose. There are two types of CBH. '''CBHI''' cleaves progressively from the reducing end while '''CBHII''' cleaves progressively from the nonreducing end of cellulose.
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'''Cellobiohydrolase''' (CBH) is a cellulase which degrades cellulose by hydrolysing the 1,4-β-D-glycosidic bonds. CBH is an exocellulase which cleaves two to four units from the ends of cellulose. There are two types of CBH. '''CBHI''' cleaves progressively from the reducing end while '''CBHII''' cleaves progressively from the nonreducing end of cellulose.<ref>PMID:9466911</ref>
==Structural highlights ==
==Structural highlights ==

Revision as of 10:59, 30 November 2015

Glycosylated cellobiohydrolase I catalytic domain complex with cellobiose and Cd+2 ions (yellow) (PDB code 3cel)

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3D structures of cellobiohydrolase

Updated on 30-November-2015

References

  1. Divne C, Stahlberg J, Teeri TT, Jones TA. High-resolution crystal structures reveal how a cellulose chain is bound in the 50 A long tunnel of cellobiohydrolase I from Trichoderma reesei. J Mol Biol. 1998 Jan 16;275(2):309-25. PMID:9466911 doi:http://dx.doi.org/10.1006/jmbi.1997.1437
  2. Stahlberg J, Divne C, Koivula A, Piens K, Claeyssens M, Teeri TT, Jones TA. Activity studies and crystal structures of catalytically deficient mutants of cellobiohydrolase I from Trichoderma reesei. J Mol Biol. 1996 Nov 29;264(2):337-49. PMID:8951380 doi:http://dx.doi.org/10.1006/jmbi.1996.0644

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Michal Harel, Alexander Berchansky, Karsten Theis

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