4d4w
From Proteopedia
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| - | ''' | + | ==Solution structure of human MBD1 CXXC1 domain== |
| - | + | <StructureSection load='4d4w' size='340' side='right' caption='[[4d4w]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4d4w]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D4W FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d4w OCA], [http://pdbe.org/4d4w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d4w RCSB], [http://www.ebi.ac.uk/pdbsum/4d4w PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/MBD1_HUMAN MBD1_HUMAN]] Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.<ref>PMID:9207790</ref> <ref>PMID:10454587</ref> <ref>PMID:9774669</ref> <ref>PMID:10648624</ref> <ref>PMID:12711603</ref> <ref>PMID:12665582</ref> <ref>PMID:12697822</ref> <ref>PMID:14610093</ref> <ref>PMID:15327775</ref> <ref>PMID:14555760</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Smith, B O]] | ||
[[Category: Thomson, R]] | [[Category: Thomson, R]] | ||
| - | [[Category: | + | [[Category: Transcription]] |
Revision as of 19:04, 30 November 2015
Solution structure of human MBD1 CXXC1 domain
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