5abh
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==Structure of GH84 with ligand== |
| + | <StructureSection load='5abh' size='340' side='right' caption='[[5abh]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5abh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ABH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ABH FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=YWN:2-[(2R,3S,4R,5R)-5-(HYDROXYMETHYL)-3,4-BIS(OXIDANYL)-1-PENTYL-PYRROLIDIN-2-YL]-N-METHYL-ETHANAMIDE'>YWN</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5abe|5abe]], [[5abf|5abf]], [[5abg|5abg]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5abh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5abh OCA], [http://pdbe.org/5abh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5abh RCSB], [http://www.ebi.ac.uk/pdbsum/5abh PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/OGA_BACTN OGA_BACTN]] Biological function unknown. Capable of hydrolyzing the glycosidic link of O-GlcNAcylated proteins. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Pyrrolidine-based iminocyclitols are a promising class of glycosidase inhibitors. Reported herein is a convenient epimerization strategy that provides direct access to a range of stereoisomeric iminocyclitol inhibitors of O-GlcNAcase (OGA), the enzyme responsible for catalyzing removal of O-GlcNAc from nucleocytoplasmic proteins. Structural details regarding the binding of these inhibitors to a bacterial homologue of OGA reveal the basis for potency. These compounds are orally available and permeate into rodent brain to increase O-GlcNAc, and should prove useful tools for studying the role of OGA in health and disease. | ||
| - | + | A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors.,Bergeron-Brlek M, Goodwin-Tindall J, Cekic N, Roth C, Zandberg WF, Shan X, Varghese V, Chan S, Davies GJ, Vocadlo DJ, Britton R Angew Chem Int Ed Engl. 2015 Nov 6. doi: 10.1002/anie.201507985. PMID:26545827<ref>PMID:26545827</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 5abh" style="background-color:#fffaf0;"></div> | |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bergeron-Brlek, M]] | ||
[[Category: Britton, R]] | [[Category: Britton, R]] | ||
| + | [[Category: Cekic, N]] | ||
[[Category: Chan, S]] | [[Category: Chan, S]] | ||
| + | [[Category: Davies, G J]] | ||
| + | [[Category: Goodwin-Tindall, J]] | ||
| + | [[Category: Roth, C]] | ||
| + | [[Category: Shan, X]] | ||
[[Category: Varghese, V]] | [[Category: Varghese, V]] | ||
| - | [[Category: | + | [[Category: Vocadlo, D J]] |
| - | [[Category: | + | [[Category: Zandberg, W F]] |
| - | [[Category: | + | [[Category: Hydrolase]] |
| - | [[Category: | + | [[Category: Inhibitor]] |
| - | [[Category: | + | [[Category: Tim-barrel]] |
| - | + | ||
| - | + | ||
| - | + | ||
Revision as of 20:45, 30 November 2015
Structure of GH84 with ligand
| |||||||||||
Categories: Bergeron-Brlek, M | Britton, R | Cekic, N | Chan, S | Davies, G J | Goodwin-Tindall, J | Roth, C | Shan, X | Varghese, V | Vocadlo, D J | Zandberg, W F | Hydrolase | Inhibitor | Tim-barrel
