5df1
From Proteopedia
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| - | ''' | + | ==Iridoid synthase from Catharanthus roseus - ternary complex with NADP+ and geranic acid== |
| + | <StructureSection load='5df1' size='340' side='right' caption='[[5df1]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5df1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DF1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DF1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=58X:(2E)-3,7-DIMETHYLOCTA-2,6-DIENOIC+ACID'>58X</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Iridoid_synthase Iridoid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.99 1.3.1.99] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5df1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5df1 OCA], [http://pdbe.org/5df1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5df1 RCSB], [http://www.ebi.ac.uk/pdbsum/5df1 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The carbon skeleton of ecologically and pharmacologically important iridoid monoterpenes is formed in a reductive cyclization reaction unrelated to canonical terpene cyclization. Here we report the crystal structure of the recently discovered iridoid cyclase (from Catharanthus roseus) bound to a mechanism-inspired inhibitor that illuminates substrate binding and catalytic function of the enzyme. Key features that distinguish iridoid synthase from its close homolog progesterone 5beta-reductase are highlighted. | ||
| - | + | Structural determinants of reductive terpene cyclization in iridoid biosynthesis.,Kries H, Caputi L, Stevenson CE, Kamileen MO, Sherden NH, Geu-Flores F, Lawson DM, O'Connor SE Nat Chem Biol. 2015 Nov 9. doi: 10.1038/nchembio.1955. PMID:26551396<ref>PMID:26551396</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 5df1" style="background-color:#fffaf0;"></div> | |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Iridoid synthase]] | ||
| + | [[Category: Caputi, L]] | ||
| + | [[Category: Connor, S E.O]] | ||
| + | [[Category: Geu-Flores, F]] | ||
| + | [[Category: Kamileen, M O]] | ||
[[Category: Kries, H]] | [[Category: Kries, H]] | ||
| - | [[Category: | + | [[Category: Lawson, D M]] |
| - | [[Category: Sherden, N | + | [[Category: Sherden, N H]] |
| - | [[Category: | + | [[Category: Stevenson, C E.M]] |
| - | [[Category: | + | [[Category: Catharanthus roseus]] |
| - | [[Category: | + | [[Category: Nadph-dependent]] |
| - | [[Category: | + | [[Category: Oxidoreductase]] |
| - | [[Category: | + | [[Category: Short chain dehydrogenase]] |
Revision as of 21:00, 30 November 2015
Iridoid synthase from Catharanthus roseus - ternary complex with NADP+ and geranic acid
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