4rax
From Proteopedia
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- | ''' | + | ==A regulatory domain of an ion channel== |
- | + | <StructureSection load='4rax' size='340' side='right' caption='[[4rax]], [[Resolution|resolution]] 1.45Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[4rax]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RAX FirstGlance]. <br> | |
- | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rax OCA], [http://pdbe.org/4rax PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rax RCSB], [http://www.ebi.ac.uk/pdbsum/4rax PDBsum]</span></td></tr> | |
- | + | </table> | |
- | + | == Function == | |
- | [[ | + | [[http://www.uniprot.org/uniprot/PIEZ1_MOUSE PIEZ1_MOUSE]] Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.<ref>PMID:20813920</ref> <ref>PMID:22343900</ref> <ref>PMID:24157948</ref> <ref>PMID:24958852</ref> <ref>PMID:25119035</ref> |
- | [[ | + | == References == |
+ | <references/> | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
[[Category: Ge, J]] | [[Category: Ge, J]] | ||
+ | [[Category: Yang, M]] | ||
+ | [[Category: Extra-cellular]] | ||
+ | [[Category: Novel structure]] | ||
+ | [[Category: Regulatory]] | ||
+ | [[Category: Regulatory domain]] | ||
+ | [[Category: Sandwich fold]] | ||
+ | [[Category: Structural protein]] |
Revision as of 21:46, 30 November 2015
A regulatory domain of an ion channel
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