190d
From Proteopedia
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|PDB= 190d |SIZE=350|CAPTION= <scene name='initialview01'>190d</scene>, resolution 1.800Å | |PDB= 190d |SIZE=350|CAPTION= <scene name='initialview01'>190d</scene>, resolution 1.800Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=190d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=190d OCA], [http://www.ebi.ac.uk/pdbsum/190d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=190d RCSB]</span> | ||
}} | }} | ||
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[[Category: u-dna]] | [[Category: u-dna]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:29:47 2008'' |
Revision as of 15:29, 30 March 2008
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| , resolution 1.800Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF A FOUR-STRANDED INTERCALATED DNA: D(C4)
Overview
The crystal structure of d(C4) solved at 2.3-A resolution reveals a four-stranded molecule composed of two interdigitated or intercalated duplexes. The duplexes are held together by hemiprotonated cytosine-cytosine base pairs and are parallel stranded, but the two duplexes point in opposite directions. The molecule has a slow right-handed twist of 12.4 degrees between covalently linked cytosine base pairs, and the base stacking distance is 3.1 A. This is in general agreement with the NMR studies. A biological role for DNA in this conformation is suggested.
About this Structure
190D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Crystal structure of a four-stranded intercalated DNA: d(C4)., Chen L, Cai L, Zhang X, Rich A, Biochemistry. 1994 Nov 22;33(46):13540-6. PMID:7947764
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