1a0p
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a0p OCA], [http://www.ebi.ac.uk/pdbsum/1a0p PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a0p RCSB]</span> | ||
}} | }} | ||
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[[Category: xerd]] | [[Category: xerd]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:30:44 2008'' |
Revision as of 15:30, 30 March 2008
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| , resolution 2.5Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SITE-SPECIFIC RECOMBINASE, XERD
Overview
The structure of the site-specific recombinase, XerD, that functions in circular chromosome separation, has been solved at 2.5 A resolution and reveals that the protein comprises two domains. The C-terminal domain contains two conserved sequence motifs that are located in similar positions in the structures of XerD, lambda and HP1 integrases. However, the extreme C-terminal regions of the three proteins, containing the active site tyrosine, are very different. In XerD, the arrangement of active site residues supports a cis cleavage mechanism. Biochemical evidence for DNA bending is encompassed in a model that accommodates extensive biochemical and genetic data, and in which the DNA is wrapped around an alpha-helix in a manner similar to that observed for CAP complexed with DNA.
About this Structure
1A0P is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Crystal structure of the site-specific recombinase, XerD., Subramanya HS, Arciszewska LK, Baker RA, Bird LE, Sherratt DJ, Wigley DB, EMBO J. 1997 Sep 1;16(17):5178-87. PMID:9311978
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