1a58
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6279 Brugia malayi]) | |GENE= CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6279 Brugia malayi]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a58 OCA], [http://www.ebi.ac.uk/pdbsum/1a58 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a58 RCSB]</span> | ||
}} | }} | ||
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[[Category: ppiase]] | [[Category: ppiase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:33:35 2008'' |
Revision as of 15:33, 30 March 2008
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| , resolution 1.95Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | CYCLOPHILIN (Brugia malayi) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CYCLOPHILIN FROM BRUGIA MALAYI
Overview
A structure of residues 1-177 of the cyclophilin domain of a large divergent cyclophilin from the filarial nematode parasite Brugia malayi has been crystallised and solved in two different crystal forms. The active site has a similar structure to that of human cyclophilin A. Two of the 13 residues important in forming the human cyclophilin A/cyclosporin A complex are altered in the B. malayi cyclophilin and explain the relatively poor inhibition of peptidyl prolyl isomerase activity by cyclosporin A.
About this Structure
1A58 is a Single protein structure of sequence from Brugia malayi. Full crystallographic information is available from OCA.
Reference
The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi., Taylor P, Page AP, Kontopidis G, Husi H, Walkinshaw MD, FEBS Lett. 1998 Mar 27;425(2):361-6. PMID:9559680
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