1a6e
From Proteopedia
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|PDB= 1a6e |SIZE=350|CAPTION= <scene name='initialview01'>1a6e</scene>, resolution 3.2Å | |PDB= 1a6e |SIZE=350|CAPTION= <scene name='initialview01'>1a6e</scene>, resolution 3.2Å | ||
|SITE= <scene name='pdbsite=ASB:Residue+Numbering+According+To+Alpha-Type+Subunit'>ASB</scene> and <scene name='pdbsite=ASE:Residue+Numbering+According+To+Alpha-Type+Subunit'>ASE</scene> | |SITE= <scene name='pdbsite=ASB:Residue+Numbering+According+To+Alpha-Type+Subunit'>ASB</scene> and <scene name='pdbsite=ASE:Residue+Numbering+According+To+Alpha-Type+Subunit'>ASE</scene> | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AF3:ALUMINUM+FLUORIDE'>AF3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a6e OCA], [http://www.ebi.ac.uk/pdbsum/1a6e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a6e RCSB]</span> | ||
}} | }} | ||
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[[Category: Stetter, K O.]] | [[Category: Stetter, K O.]] | ||
[[Category: Stock, D.]] | [[Category: Stock, D.]] | ||
| - | [[Category: ADP]] | ||
| - | [[Category: AF3]] | ||
| - | [[Category: MG]] | ||
[[Category: atp hydrolysis]] | [[Category: atp hydrolysis]] | ||
[[Category: atpase]] | [[Category: atpase]] | ||
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[[Category: tric]] | [[Category: tric]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:34:15 2008'' |
Revision as of 15:34, 30 March 2008
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| , resolution 3.2Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | and | ||||||
| Ligands: | , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THERMOSOME-MG-ADP-ALF3 COMPLEX
Overview
We have determined to 2.6 A resolution the crystal structure of the thermosome, the archaeal group II chaperonin from T. acidophilum. The hexadecameric homolog of the eukaryotic chaperonin CCT/TRiC shows an (alphabeta)4(alphabeta)4 subunit assembly. Domain folds are homologous to GroEL but form a novel type of inter-ring contact. The domain arrangement resembles the GroEL-GroES cis-ring. Parts of the apical domains form a lid creating a closed conformation. The lid substitutes for a GroES-like cochaperonin that is absent in the CCT/TRiC system. The central cavity has a polar surface implicated in protein folding. Binding of the transition state analog Mg-ADP-AIF3 suggests that the closed conformation corresponds to the ATP form.
About this Structure
1A6E is a Protein complex structure of sequences from Thermoplasma acidophilum. Full crystallographic information is available from OCA.
Reference
Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT., Ditzel L, Lowe J, Stock D, Stetter KO, Huber H, Huber R, Steinbacher S, Cell. 1998 Apr 3;93(1):125-38. PMID:9546398
Page seeded by OCA on Sun Mar 30 18:34:15 2008
