1a8a
From Proteopedia
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|PDB= 1a8a |SIZE=350|CAPTION= <scene name='initialview01'>1a8a</scene>, resolution 1.9Å | |PDB= 1a8a |SIZE=350|CAPTION= <scene name='initialview01'>1a8a</scene>, resolution 1.9Å | ||
|SITE= <scene name='pdbsite=GSE:Gse+Binding+Site+(Includes+2+Ca+Ions)'>GSE</scene> | |SITE= <scene name='pdbsite=GSE:Gse+Binding+Site+(Includes+2+Ca+Ions)'>GSE</scene> | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GSE:L-ALPHA-GLYCEROPHOSPHORYLSERINE'>GSE</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8a OCA], [http://www.ebi.ac.uk/pdbsum/1a8a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a8a RCSB]</span> | ||
}} | }} | ||
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[[Category: Seaton, B A.]] | [[Category: Seaton, B A.]] | ||
[[Category: Swairjo, M A.]] | [[Category: Swairjo, M A.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: GSE]] | ||
[[Category: calcium binding protein]] | [[Category: calcium binding protein]] | ||
[[Category: membrane binding protein]] | [[Category: membrane binding protein]] | ||
[[Category: phospholipid analog]] | [[Category: phospholipid analog]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:35:24 2008'' |
Revision as of 15:35, 30 March 2008
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| , resolution 1.9Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOSERINE
Overview
Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo.
About this Structure
1A8A is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:7583670
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