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1a8a

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|PDB= 1a8a |SIZE=350|CAPTION= <scene name='initialview01'>1a8a</scene>, resolution 1.9&Aring;
|PDB= 1a8a |SIZE=350|CAPTION= <scene name='initialview01'>1a8a</scene>, resolution 1.9&Aring;
|SITE= <scene name='pdbsite=GSE:Gse+Binding+Site+(Includes+2+Ca+Ions)'>GSE</scene>
|SITE= <scene name='pdbsite=GSE:Gse+Binding+Site+(Includes+2+Ca+Ions)'>GSE</scene>
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=GSE:L-ALPHA-GLYCEROPHOSPHORYLSERINE'>GSE</scene>
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GSE:L-ALPHA-GLYCEROPHOSPHORYLSERINE'>GSE</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
 +
|DOMAIN=
 +
|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8a OCA], [http://www.ebi.ac.uk/pdbsum/1a8a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a8a RCSB]</span>
}}
}}
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[[Category: Seaton, B A.]]
[[Category: Seaton, B A.]]
[[Category: Swairjo, M A.]]
[[Category: Swairjo, M A.]]
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[[Category: CA]]
 
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[[Category: GSE]]
 
[[Category: calcium binding protein]]
[[Category: calcium binding protein]]
[[Category: membrane binding protein]]
[[Category: membrane binding protein]]
[[Category: phospholipid analog]]
[[Category: phospholipid analog]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:54:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:35:24 2008''

Revision as of 15:35, 30 March 2008

Image:1a8a.gif


PDB ID 1a8a

Drag the structure with the mouse to rotate
, resolution 1.9Å
Sites:
Ligands: ,
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOSERINE


Overview

Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo.

About this Structure

1A8A is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:7583670

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