5daw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
==Fe(II)/(alpha)ketoglutarate-dependent dioxygenase AsqJ in complex with cyclopeptin==
 +
<StructureSection load='5daw' size='340' side='right' caption='[[5daw]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[5daw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DAW FirstGlance]. <br>
 +
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=58K:CYCLOPEPTIN'>58K</scene>, <scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
 +
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dap|5dap]]</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5daw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5daw OCA], [http://pdbe.org/5daw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5daw RCSB], [http://www.ebi.ac.uk/pdbsum/5daw PDBsum]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Multienzymatic cascades are responsible for the biosynthesis of natural products and represent a source of inspiration for synthetic chemists. The FeII /alpha-ketoglutarate-dependent dioxygenase AsqJ from Aspergillus nidulans is outstanding because it stereoselectively catalyzes both a ferryl-induced desaturation reaction and epoxidation on a benzodiazepinedione. Interestingly, the enzymatically formed spiro epoxide spring-loads the 6,7-bicyclic skeleton for non-enzymatic rearrangement into the 6,6-bicyclic scaffold of the quinolone alkaloid 4'-methoxyviridicatin. Herein, we report different crystal structures of the protein in the absence and presence of synthesized substrates, surrogates, and intermediates that mimic the various stages of the reaction cycle of this exceptional dioxygenase.
-
The entry 5daw is ON HOLD until Paper Publication
+
Structure of the Dioxygenase AsqJ: Mechanistic Insights into a One-Pot Multistep Quinolone Antibiotic Biosynthesis.,Brauer A, Beck P, Hintermann L, Groll M Angew Chem Int Ed Engl. 2015 Nov 10. doi: 10.1002/anie.201507835. PMID:26553478<ref>PMID:26553478</ref>
-
Authors: Groll, M., Braeuer, A.
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
Description: Fe(II)/(alpha)ketoglutarate-dependent dioxygenase AsqJ in complex with cyclopeptin
+
<div class="pdbe-citations 5daw" style="background-color:#fffaf0;"></div>
-
[[Category: Unreleased Structures]]
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Braeuer, A]]
[[Category: Groll, M]]
[[Category: Groll, M]]
-
[[Category: Braeuer, A]]
+
[[Category: Alkaloid]]
 +
[[Category: Antibiotic]]
 +
[[Category: Biosynthesis]]
 +
[[Category: Cyclopeptin]]
 +
[[Category: Desaturase]]
 +
[[Category: Epoxidase]]
 +
[[Category: Fragmentation]]
 +
[[Category: Oxidoreductase]]
 +
[[Category: Viridicatin]]

Revision as of 04:37, 1 December 2015

Fe(II)/(alpha)ketoglutarate-dependent dioxygenase AsqJ in complex with cyclopeptin

5daw, resolution 1.60Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5daw"
Personal tools