4ruh
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==Crystal structure of Human Carnosinase-2 (CN2) in complex with inhibitor, Bestatin at 2.25 A== |
| - | + | <StructureSection load='4ruh' size='340' side='right' caption='[[4ruh]], [[Resolution|resolution]] 2.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ruh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RUH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BES:2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC+ACID'>BES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytosol_nonspecific_dipeptidase Cytosol nonspecific dipeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.13.18 3.4.13.18] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ruh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ruh OCA], [http://pdbe.org/4ruh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ruh RCSB], [http://www.ebi.ac.uk/pdbsum/4ruh PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/CNDP2_HUMAN CNDP2_HUMAN]] Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells.<ref>PMID:17121880</ref> <ref>PMID:19346245</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cytosol nonspecific dipeptidase]] | ||
[[Category: Kaushik, A]] | [[Category: Kaushik, A]] | ||
| - | [[Category: | + | [[Category: Kumaran, S]] |
| - | [[Category: Singh, A | + | [[Category: Singh, A K]] |
| + | [[Category: Singh, R P]] | ||
| + | [[Category: Pandya, V]] | ||
| + | [[Category: Carboxypeptidase]] | ||
| + | [[Category: Cofactor manganese]] | ||
| + | [[Category: Cytosolic]] | ||
| + | [[Category: Enzyme function initiative]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Metalloprotease]] | ||
| + | [[Category: Protease]] | ||
| + | [[Category: Structural genomic]] | ||
Revision as of 04:41, 1 December 2015
Crystal structure of Human Carnosinase-2 (CN2) in complex with inhibitor, Bestatin at 2.25 A
| |||||||||||
