3x22
From Proteopedia
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| - | ''' | + | ==Crystal structure of Escherichia coli nitroreductase NfsB mutant N71S/F123A/F124W== |
| - | + | <StructureSection load='3x22' size='340' side='right' caption='[[3x22]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3x22]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X22 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X22 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ds7|1ds7]], [[3x21|3x21]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6,7-dihydropteridine_reductase 6,7-dihydropteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.34 1.5.1.34] </span></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x22 OCA], [http://pdbe.org/3x22 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3x22 RCSB], [http://www.ebi.ac.uk/pdbsum/3x22 PDBsum]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NFNB_ECOLI NFNB_ECOLI]] Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species.<ref>PMID:15684426</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: 6,7-dihydropteridine reductase]] | ||
[[Category: Bai, J]] | [[Category: Bai, J]] | ||
[[Category: Yang, J]] | [[Category: Yang, J]] | ||
| + | [[Category: Yang, Q]] | ||
[[Category: Zhou, Y]] | [[Category: Zhou, Y]] | ||
| + | [[Category: Cb1954]] | ||
| + | [[Category: Nitroreductase]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Prodrug activation]] | ||
| + | [[Category: Regioselectivity]] | ||
Revision as of 18:54, 1 December 2015
Crystal structure of Escherichia coli nitroreductase NfsB mutant N71S/F123A/F124W
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