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4rms

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'''Unreleased structure'''
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==Crystal structure of the D53N Beta-2 Microglobulin mutant==
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<StructureSection load='4rms' size='340' side='right' caption='[[4rms]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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The entry 4rms is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4rms]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RMS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RMS FirstGlance]. <br>
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Authors: de Rosa, M., Bolognesi, M., Ricagno, S.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yxf|2yxf]], [[4fxl|4fxl]], [[4rmq|4rmq]], [[4rmr|4rmr]], [[4rmt|4rmt]], [[4rmu|4rmu]], [[4rmv|4rmv]], [[4rmw|4rmw]]</td></tr>
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Description: Crystal structure of the D53N Beta-2 Microglobulin mutant
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rms OCA], [http://pdbe.org/4rms PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rms RCSB], [http://www.ebi.ac.uk/pdbsum/4rms PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Ricagno, S]]
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== Disease ==
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[[Category: De Rosa, M]]
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bolognesi, M]]
[[Category: Bolognesi, M]]
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[[Category: Ricagno, S]]
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[[Category: Rosa, M de]]
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[[Category: Amyloidosis]]
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[[Category: Beta-sandwitch]]
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[[Category: Genetic disease]]
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[[Category: Immune system]]
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[[Category: Immunoglobin]]
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[[Category: Mhc class i]]
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[[Category: Pathologic mutation]]

Revision as of 18:54, 1 December 2015

Crystal structure of the D53N Beta-2 Microglobulin mutant

4rms, resolution 1.70Å

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