5dp2

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m (Protected "5dp2" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==CurF ER cyclopropanase from curacin A biosynthetic pathway==
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<StructureSection load='5dp2' size='340' side='right' caption='[[5dp2]], [[Resolution|resolution]] 0.96&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5dp2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DP2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dov|5dov]], [[5doz|5doz]], [[5dp1|5dp1]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dp2 OCA], [http://pdbe.org/5dp2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dp2 RCSB], [http://www.ebi.ac.uk/pdbsum/5dp2 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The natural product curacin A, a potent anticancer agent, contains a rare cyclopropane group. The five enzymes for cyclopropane biosynthesis are highly similar to enzymes that generate a vinyl chloride moiety in the jamaicamide natural product. The structural biology of this remarkable catalytic adaptability is probed with high-resolution crystal structures of the curacin cyclopropanase (CurF ER), an in vitro enoyl reductase (JamJ ER), and a canonical curacin enoyl reductase (CurK ER). The JamJ and CurK ERs catalyze NADPH-dependent double bond reductions typical of enoyl reductases (ERs) of the medium-chain dehydrogenase reductase (MDR) superfamily. Cyclopropane formation by CurF ER is specified by a short loop which, when transplanted to JamJ ER, confers cyclopropanase activity on the chimeric enzyme. Detection of an adduct of NADPH with the model substrate crotonyl-CoA provides indirect support for a recent proposal of a C2-ene intermediate on the reaction pathway of MDR enoyl-thioester reductases.
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The entry 5dp2 is ON HOLD until Paper Publication
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Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase.,Khare D, Hale WA, Tripathi A, Gu L, Sherman DH, Gerwick WH, Hakansson K, Smith JL Structure. 2015 Oct 24. pii: S0969-2126(15)00405-0. doi:, 10.1016/j.str.2015.09.013. PMID:26526850<ref>PMID:26526850</ref>
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Authors: Khare, D., Smith, J.L.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description: CurF ER cyclopropanase from curacin A biosynthetic pathway
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<div class="pdbe-citations 5dp2" style="background-color:#fffaf0;"></div>
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[[Category: Unreleased Structures]]
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== References ==
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[[Category: Smith, J.L]]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Khare, D]]
[[Category: Khare, D]]
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[[Category: Smith, J L]]
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[[Category: Curacin some]]
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[[Category: Cyclopropane]]
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[[Category: Oxidoreductase]]
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[[Category: Polyketide synthase]]

Revision as of 19:01, 1 December 2015

CurF ER cyclopropanase from curacin A biosynthetic pathway

5dp2, resolution 0.96Å

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