5e6p

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m (Protected "5e6p" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==PlexinB2 cytoplasmic region/PDZ-RhoGEF PDZ domain complex==
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<StructureSection load='5e6p' size='340' side='right' caption='[[5e6p]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
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The entry 5e6p is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5e6p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E6P FirstGlance]. <br>
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Authors: Pascoe, H.G., Zhang, X.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e6p OCA], [http://pdbe.org/5e6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e6p RCSB], [http://www.ebi.ac.uk/pdbsum/5e6p PDBsum]</span></td></tr>
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</table>
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Description:
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== Function ==
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[[Category: Unreleased Structures]]
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[[http://www.uniprot.org/uniprot/PLXB2_MOUSE PLXB2_MOUSE]] Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro).<ref>PMID:17554007</ref> <ref>PMID:19948886</ref> <ref>PMID:21122816</ref> <ref>PMID:21966369</ref> [[http://www.uniprot.org/uniprot/ARHGB_HUMAN ARHGB_HUMAN]] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Pascoe, H G]]
[[Category: Zhang, X]]
[[Category: Zhang, X]]
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[[Category: Pascoe, H.G]]
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[[Category: Complex]]
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[[Category: Pdz]]
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[[Category: Pdz-rhogef]]
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[[Category: Plexin]]
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[[Category: Signaling protein]]

Revision as of 19:01, 1 December 2015

PlexinB2 cytoplasmic region/PDZ-RhoGEF PDZ domain complex

5e6p, resolution 3.21Å

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